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Carboplatin

別名: NSC 241240, JM-8, CBDCA 中文名稱：卡鉑

鉑類藥物不建議使用DMSO溶解，易失活！

Carboplatin是 CDDP 的衍生物，是一種 DNA 合成抑制劑，在 A2780、SKOV-3、IGROV-1 和 HX62 細(xì)胞中可與 DNA 結(jié)合，抑制復(fù)制和轉(zhuǎn)錄，誘導(dǎo)細(xì)胞死亡并干擾細(xì)胞的修復(fù)機(jī)制發(fā)揮作用。它誘導(dǎo) DNA 鏈間交聯(lián)和 DNA-蛋白質(zhì)交聯(lián)的形成。在溶液中不穩(wěn)定，請現(xiàn)配現(xiàn)用！鉑類藥物不建議用DMSO溶解，易失活！

Carboplatin Chemical Structure

Carboplatin Chemical Structure

CAS: 41575-94-4

規(guī)格 價(jià)格 庫存 購買數(shù)量
50mg 630.25 現(xiàn)貨
200mg 1367.43 現(xiàn)貨
1g 4013.1 現(xiàn)貨
10g 22686.3 現(xiàn)貨
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Carboplatin相關(guān)產(chǎn)品

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系 實(shí)驗(yàn)類型 給藥濃度 孵育時(shí)間 活性描述 文獻(xiàn)信息
H460? Growth Inhibition Assay 7.9 μM 24 h shows a radiosensitizing effect to X-rays 25599995
A549/CDDP Growth Inhibition Assay 0.2-4000 μM 72 h IC50=240?±?45.7 μM 25625243
A549 Growth Inhibition Assay 0.2-4000 μM 72 h IC50=126 ± 5.0 μM 25625243
A-549? Fuction Assay 0.5 μM 48 h inhibits of cell migration? 25755690
A-549? Fuction Assay 0.5 μM 48 h shows aberrant microtubule disruption 25755690
A-549? Apoptosis Assay 0.5 μM 48 h shows early apoptosis features including blebbing and chromatin condensation 25755690
A-549? Growth Inhibition Assay 0.5 μM 24 h inhibits cell growth significantly 25755690
MCF7 Growth Inhibition Assay 20 μM 72 h induces cell death of HP1β-depleted MCF7 cells 25769025
T47D Growth Inhibition Assay 0-220 μg/ml 72 h IC50?= 48.9 μM 25837691
MDA-MB-231 Growth Inhibition Assay 0-220 μg/ml 72 h IC50?= 86 μM 25837691
H1975 Growth Inhibition Assay 25 μM 24 h inhibits cell growth 25917317
A549 Growth Inhibition Assay 25 μM 24 h inhibits cell growth 25917317
H1975 Fuction Assay 0/25/50 μM 24 h upregulates miR-218 expression 25917317
A549 Fuction Assay 0/25/50 μM 24 h upregulates miR-218 expression 25917317
H1975 Fuction Assay 0/25/50 μM 24 h downregulates miR-205 expression? 25917317
A549 Fuction Assay 0/25/50 μM 24 h downregulates miR-205 expression? 25917317
SKOV3 Apoptosis Assay 2 μg/ml 48 h induces apoptosis 26125273
SKOV3 Growth Inhibition Assay 0-4 μg/ml 24/48/72 h inhibits cell viability dose and time dependently 26125273
SKOV3 Growth Inhibition Assay 60 mg/ml 1-5 d inhibits cell viability time dependently 26137043
Tca8113/PYM? Growth Inhibition Assay 2-25?μM 72 h inhibits cell viability dose dependently 26137105
Tca8113/CBP? Growth Inhibition Assay 2-25?μM 72 h inhibits cell viability dose dependently 26137105
Tca8113/ut? Growth Inhibition Assay 2-25?μM 72 h inhibits cell viability dose dependently 26137105
PC9 Apoptosis Assay 100 μM 72 h induces apoptosis 24618809
A549? Apoptosis Assay 100 μM 72 h induces apoptosis 24618809
IMR-32 Fuction Assay 10 μM? induces apoptosis significantly combined with GSK2830371 25658463
CHP-134? Fuction Assay 10 μM? induces apoptosis significantly combined with GSK2830371 25658463
IMR-32 Growth Inhibition Assay 1 μM inhibits significant cell growth combined with GSK2830371 25658463
CHP-134? Growth Inhibition Assay 1 μM inhibits significant cell growth combined with GSK2830371 25658463
OSA Clonogenic Assay 2.5/5 μM results in lower colony formation as compared to either BMI1 siRNA treatment 26110620
HeLa Growth Inhibition Assay 5-80 μM inhibits cell growth dose dependently 25109360
MCF-7 Growth Inhibition Assay 5-80 μM inhibits cell growth dose dependently 25109360
MDA-MB-231 Growth Inhibition Assay 5-80 μM inhibits cell growth dose dependently 25109360
OVCAR-3 Growth Inhibition Assay 72 h IC50=32.6 μM 25520132
SW626 Growth Inhibition Assay 72 h IC50=97.0 μM 25520132
A2780 Growth Inhibition Assay 72 h IC50=145.7 μM 25520132
3AO Growth Inhibition Assay 72 h IC50=63.4 μM 25520132
OVCAR-8 Growth Inhibition Assay 72 h IC50=96.0 μM 25520132
ES-2 Growth Inhibition Assay 72 h IC50=14.6 μM 25520132
SK-OV-3 Growth Inhibition Assay 72 h IC50=104.8 μM 25520132
RGE Growth Inhibition Assay 72?h? IC80=63 ± 7.4 μM 25565603
NRK-52E Growth Inhibition Assay 72?h? IC80=179 ± 9.5 μM 25565603
RGE Growth Inhibition Assay 72?h? IC50=22 ± 7.4 μM 25565603
NRK-52E Growth Inhibition Assay 72?h? IC50=100 ± 12.9 μM 25565603
H460? Growth Inhibition Assay 24 h IC50=7.9 μM 25599995
CaOV3 Growth Inhibition Assay 72 h IC50=86.1 μM 25068849
OVCAR-3 Growth Inhibition Assay 72 h IC50=179.5 μM 25068849
OVCAR-5 Growth Inhibition Assay 72 h IC50=75.7 μM 25068849
SKOV-3 Growth Inhibition Assay 72 h IC50=504 μM 25068849
OVCAR-4 Growth Inhibition Assay 72 h IC50=290.6 μM 25068849
OVCAR-8 Growth Inhibition Assay 72 h IC50=690.2 μM 25068849
MA148 Growth Inhibition Assay 24 h IC50=83.6?±?1.4 μg/ml 24831091
A549 Growth Inhibition Assay 24 h IC50=776.0?±?1.9 μg/ml 24831091
MDA-MB-231 Growth Inhibition Assay 24 h IC50=748.0?±?1.1 μg/ml 24831091
NCI-ADR/RES? Growth Inhibition Assay 24 h IC50=1753.0?±?4.4 μg/ml 24831091
MA148 Growth Inhibition Assay 48 h IC50=28.1?±?1.0 μg/ml 24831091
A549 Growth Inhibition Assay 48 h IC50=118.0?±?1.2 μg/ml 24831091
MDA-MB-231 Growth Inhibition Assay 48 h IC50=183.0?±?1.2 μg/ml 24831091
NCI-ADR/RES? Growth Inhibition Assay 48 h IC50=193.0?±?1.9 μg/ml 24831091
MA148 Growth Inhibition Assay 72 h IC50=13.7?±?1.2 μg/ml 24831091
A549 Growth Inhibition Assay 72 h IC50=64.3?±?1.1 μg/ml 24831091
MDA-MB-231 Growth Inhibition Assay 72 h IC50=99.5?±?1.1 μg/ml 24831091
NCI-ADR/RES? Growth Inhibition Assay 72 h IC50=37.4?±?1.7 μg/ml 24831091
A549 Growth Inhibition Assay 72 h IC50=152.409 μM 24721323
NCI-H157 Growth Inhibition Assay 72 h IC50=89.977 μM 24721323
PC9 Growth Inhibition Assay 72 h GC50=71.6±9.5 μM 24618809
A549? Growth Inhibition Assay 72 h GC50=136±31.6 μM? 24618809
A549 Growth Inhibition Assay 24 h IC10=1.476 nM 24396437
H1299 Growth Inhibition Assay 24 h IC10=0.443 nM 24396437
HCC15 Growth Inhibition Assay 24 h IC10=0.346 nM 24396437
H157 Growth Inhibition Assay 24 h IC10=0.81 nM 24396437
4T1 Growth Inhibition Assay IC50=84.62 ± 30.05 μM μM 25277461
A549 Growth Inhibition Assay IC50=151.56 ± 53.06 μM 25277461
FN-RMG-1-hFUT Growth Inhibition Assay IC50=118.8 ± 13.8 mg/L 25726913
RMG-1-hFUT Growth Inhibition Assay IC50=58.1 ± 2.4 mg/L 25726913
FN-RMG-1 Growth Inhibition Assay IC50=40.5 ± 4.2 mg/L μM 25726913
RMG-1 Growth Inhibition Assay IC50=28.8 ± 3.6 mg/L 25726913
MonoTCC Growth Inhibition Assay IC50=5.6?μM 25773167
MegTCC Growth Inhibition Assay IC50=4.1?μM 25773167
MCTCC Growth Inhibition Assay IC50=2.8?μM 25773167
LCTCC Growth Inhibition Assay IC50=3.8?μM 25773167
BALB/3T3 Growth Inhibition Assay IC50=14.30 ± 6.68 μM 25277461
B16 Growth Inhibition Assay IC50=64.30 ± 6.81 μM 25277461
DU 145 Growth Inhibition Assay IC50=35.04 ± 17.54 μM 25277461
FaDu Growth Inhibition Assay IC50=45.39 ± 11.50 μM 25277461
HCV-29T Growth Inhibition Assay IC50=48.57 ± 22.49 μM 25277461
HL-60 Growth Inhibition Assay IC50=11.10 ± 4.47 μM 25277461
HT-29 Growth Inhibition Assay IC50=89.16 ± 18.86 μM 25277461
H146 Growth Inhibition Assay IC50=49.6±13.1 μM 25124282
H187 Growth Inhibition Assay IC50=12.7±2.7 μM 25124282
H128 Growth Inhibition Assay IC50=106.4±9.6 μM 25124282
H69 Growth Inhibition Assay IC50=76.9±27.8 μM 25124282
H209 Growth Inhibition Assay IC50=258.1±99.8 μM 25124282
DMS153 Growth Inhibition Assay IC50=57.8±9.2 μM 25124282
H526 Growth Inhibition Assay IC50=7.2±1.7 μM 25124282
DMS114 Growth Inhibition Assay IC50=85.8±12.8 μM 25124282
DMS53 Growth Inhibition Assay IC50=146.2±36.4 μM 25124282
A2780 Growth Inhibition Assay IC50=14.0?±?1.4 μM 24209693
A2780cisR Growth Inhibition Assay IC50=48.9?±?3.9 μM 24209693
A2780ZD0473R Growth Inhibition Assay IC50=64.6?±?3.2 μM 24209693
SKOV-3 Growth Inhibition Assay IC50=43.4?±?3.9 μM 24209693
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生物活性

產(chǎn)品描述 Carboplatin是 CDDP 的衍生物，是一種 DNA 合成抑制劑，在 A2780、SKOV-3、IGROV-1 和 HX62 細(xì)胞中可與 DNA 結(jié)合，抑制復(fù)制和轉(zhuǎn)錄，誘導(dǎo)細(xì)胞死亡并干擾細(xì)胞的修復(fù)機(jī)制發(fā)揮作用。它誘導(dǎo) DNA 鏈間交聯(lián)和 DNA-蛋白質(zhì)交聯(lián)的形成。在溶液中不穩(wěn)定，請現(xiàn)配現(xiàn)用！鉑類藥物不建議用DMSO溶解，易失活！
特性 不建議使用DMSO溶解。[6]
靶點(diǎn)
DNA synthesis [1]
(A2780, SKOV-3, IGROV-1, HX62 cells)
體外研究(In Vitro)
體外研究活性

Carboplatin作用于一組人類卵巢癌細(xì)胞系，包括A2780, SKOV3,和 IGROV-1細(xì)胞，抑制細(xì)胞增殖,IC50分別為6.1 μM, 12.4 μM 和2.2 μM。[1]
細(xì)胞實(shí)驗(yàn) 細(xì)胞系 A2780, SKOV3, IGROV-1 和 HX62
濃度 0 到 200 μM
孵育時(shí)間 72 小時(shí)
方法

MTT實(shí)驗(yàn): 指數(shù)生長的A2780, SKOV3, IGROV-1和 HX62卵巢癌細(xì)胞接種在96孔板中。加入一系列濃度的Carboplatin，再溫育72小時(shí)。每組實(shí)驗(yàn)按一式三份進(jìn)行。 Sulforhodamine B (SRB)實(shí)驗(yàn):指數(shù)生長的 A2780細(xì)胞接種在96孔板中。使用濃度不斷增加的17-AAG 和Carboplatin處理細(xì)胞96小時(shí)。使用濃度不斷增加的17-AAG或Carboplatin處理細(xì)胞 24小時(shí)，研究17-AAG 或 Carboplatin處理序列的效果。選中的第一種藥劑處理細(xì)胞24小時(shí)，確保A2780細(xì)胞使用第一種藥劑至少處理雙倍時(shí)間(18-24小時(shí))。使用無菌磷酸鹽緩沖液沖洗細(xì)胞，然后補(bǔ)充培養(yǎng)基。然后，加入第二種藥劑 (第一次24小時(shí)未處理細(xì)胞的)或培養(yǎng)基，再處理96小時(shí)。所有實(shí)驗(yàn)按一式三份進(jìn)行。使用中位數(shù)效果分析方法按行之有效的原則分析聯(lián)合研究的效果。使用內(nèi)部電子表格計(jì)算聯(lián)用的效果。
實(shí)驗(yàn)圖片 檢測方法 檢測指標(biāo) 實(shí)驗(yàn)圖片 PMID
Western blot

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