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- 2x SYBR Green qPCR Master Mix
- 2x SYBR Green qPCR Master Mix(Low ROX)
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BMS309403
BMS309403是FABP4小分子抑制劑，Kd值為4 nM，對FABP4的選擇性比對FABP5和FABP3高100倍以上。
BMS309403 Chemical Structure
CAS: 300657-03-8
產(chǎn)品質(zhì)控
批次：
純度：
99.94%
99.94
BMS309403相關(guān)產(chǎn)品
| 相關(guān)化合物庫 | 代謝化合物庫 抗癌代謝化合物庫 谷氨酰胺代謝化合物庫 糖代謝化合物庫 脂代謝化合物庫 | 點擊展開 |
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細(xì)胞實驗數(shù)據(jù)示例
| 細(xì)胞系 | 實驗類型 | 給藥濃度 | 孵育時間 | 活性描述 | 文獻信息 |
|---|---|---|---|---|---|
| THP1 | Function assay | 25 uM | 3 days | Reduction of transformation of human THP1 cells to foam cells at 25 uM after 3 days relative to control | 17554340 |
| aP2+/+ macrophage cells | Function assay | 25 uM | Reduction in total cholesterol ester content in mouse aP2+/+ macrophage cells at 25 uM relative to control | 17554340 | |
| aP2-/-R macrophage cells | Function assay | 25 uM | Reduction in total cholesterol ester content in mouse aP2-/-R macrophage cells (re-expression of aP2) at 25 uM relative to control | 17554340 | |
| THP1 | Function assay | 25 uM | Increase in APOA1-mediated cholesterol in human THP1 cells at 25 uM relative to control | 17554340 | |
| THP1 | Function assay | 25 uM | Increase in ABCA1 mRNA level in human THP1 cells at 25 uM relative to control | 17554340 | |
| THP1 | Function assay | 25 uM | Increase in ABCA1 protein level in human THP1 cells at 25 uM relative to control | 17554340 | |
| aP2+/+ macrophage cells | Function assay | 25 uM | Increase in cholesterol efflux in mouse aP2+/+ macrophage cells at 25 uM relative to control | 17554340 | |
| aP2-/-R macrophage cells | Function assay | 25 uM | Increase in cholesterol efflux in mouse aP2-/-R macrophage cells (re-expression of aP2) at 25 uM relative to control | 17554340 | |
| aP2+/+ macrophage cells | Function assay | 24 hrs | Decrease in MCP1 production in mouse aP2+/+ macrophage cells after 24 hrs | 17554340 | |
| aP2-/-R macrophage cells | Function assay | 24 hrs | Decrease in MCP1 production in mouse aP2-/-R macrophage cells (re-expression of aP2) after 24 hrs | 17554340 | |
| BL21(DE3) | Function assay | Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay, Ki=0.22μM | 27460668 | ||
| BL21(DE3) | Function assay | Direct binding to His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by isothermal titration calorimetry, Kd=2.05μM | 27460668 | ||
| THP1 | Function assay | Reduction of Mcp1 expression in human THP1 cells expressing aP2 relative to control | 17554340 | ||
| aP2+/+ macrophage cells | Function assay | Reduction of Mcp1 expression mouse aP2+/+ macrophage cells relative to control | 17554340 | ||
| aP2-/-R macrophage cells | Function assay | Reduction of Mcp1 expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control | 17554340 | ||
| THP1 | Function assay | Reduction of IL1-beta expression in human THP1 cells expressing aP2 relative to control | 17554340 | ||
| aP2+/+ macrophage cells | Function assay | Reduction of IL1-beta expressed in mouse aP2+/+ macrophage cells relative to control | 17554340 | ||
| aP2-/-R macrophage cells | Function assay | Reduction of IL1-beta expressed in mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control | 17554340 | ||
| THP1 | Function assay | Reduction of IL6 expression in human THP1 cells expressing aP2 relative to control | 17554340 | ||
| aP2+/+ macrophage cells | Function assay | Reduction of IL6 expression mouse aP2+/+ macrophage cells relative to control | 17554340 | ||
| aP2-/-R macrophage cells | Function assay | Reduction of IL6 expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control | 17554340 | ||
| THP1 | Function assay | Reduction of TNF expression in human THP1 cells expressing aP2 relative to control | 17554340 | ||
| aP2+/+ macrophage cells | Function assay | Reduction of TNF expression in mouse aP2+/+ macrophage cells relative to control | 17554340 | ||
| aP2-/-R macrophage cells | Function assay | Reduction of TNF expression mouse aP2-/-R macrophage cells (re-expression of aP2) relative to control | 17554340 | ||
| 點擊查看更多細(xì)胞系數(shù)據(jù) | |||||
生物活性
| 產(chǎn)品描述 | BMS309403是FABP4小分子抑制劑，Kd值為4 nM，對FABP4的選擇性比對FABP5和FABP3高100倍以上。 | ||
|---|---|---|---|
| 靶點 |
|
化學(xué)信息&溶解度
| 分子量 | 474.55 | 分子式 | C31H26N2O3 |
| CAS號 | 300657-03-8 | SDF | -- |
| Smiles | CCC1=C(C(=NN1C2=CC=CC=C2C3=CC(=CC=C3)OCC(=O)O)C4=CC=CC=C4)C5=CC=CC=C5 | ||
| 儲存條件(自收到貨起) | 3年 -20°C 粉狀 | ||
|
體外溶解度 |
DMSO : 95 mg/mL ( (200.18 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO) Ethanol : 18 mg/mL (37.93 mM) Water : Insoluble |
摩爾濃度計算器 |
|
體內(nèi)溶解度 現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑 |
動物體內(nèi)配方計算器 | ||||
實驗計算
動物體內(nèi)配方計算器（澄清溶液）
第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）
mg/kg
g
μL
只
第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計算結(jié)果：
工作液濃度： mg/ml；
DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；
體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。
體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。
注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。
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