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Vorinostat (SAHA)

別名: MK0683, Suberoylanilide hydroxamic acid 中文名稱：伏立諾他

Vorinostat (SAHA)是一種HDAC抑制劑，無細胞試驗中IC50為~10 nM。Vorinostat 會抑制高效的HPV-18 DNA擴增。

Vorinostat (SAHA) Chemical Structure

Vorinostat (SAHA) Chemical Structure

CAS: 149647-78-9

規(guī)格 價格 庫存 購買數(shù)量
10mM (1mL in DMSO) 1558.77 現(xiàn)貨
200mg 1198.15 現(xiàn)貨
500mg 1794.86 現(xiàn)貨
2g 4013.1 現(xiàn)貨
10g 9582.3 現(xiàn)貨
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Vorinostat (SAHA)相關(guān)產(chǎn)品

相關(guān)信號通路圖

HDAC Signaling Pathways

HDAC信號通路圖

細胞實驗數(shù)據(jù)示例

細胞系 實驗類型 給藥濃度 孵育時間 活性描述 文獻信息
HCT116 Apoptosis Assay 3 μM 24 h does not induce apoptosis assessed as increase in p53 protein level 24766560
Jurkat Cytotoxic Assay 20 μM 72 h no cytotoxicity assessed as growth inhibition 24304348
MDA-MB-231 Kinase Assay 1 μM 24 h does not inhibit HDAC6 assessed as acetylation levels of tubulin 23493449
MDA-MB-231 Kinase Assay 10 μM 5 min does not inhibit HDAC2a 23493449
GM11272 Function Assay 0.1 μM 72 h does not reactivate MeCp2 mutant expression 21840716
HepG2 Function Assay 10 μM 24 h does not induce apoptosis assessed as hyperacetylation of p53 21548582
HCT116 Kinase Assay 0.3 μM 30 h does not inhibit HDAC1 assessed as induction of histone H3K9 acetylation 21080647
A549 Function Assay 5 μM 3 h does not induce autophagy assessed as increase in LC3II 20855208
SCC4 Function Assay 1 μM 10 min has no agonist activity at VDR assessed as induction of CYP24 gene expression 20452225
Caco-2 Function Assay 5 μM 24 h does not induce P21WAF1 gene expression 20143840
PANC1 Function Assay 1 μM 48 h does not increase in p27kip1 gene expression 17588744
PANC1 Function Assay 1 μM 24 h does not increase in p27kip1 gene expression 17588744
U937 Kinase Assay 1 μM 24 h has no effect on alpha tubulin acetylation 17447750
U937 Kinase Assay 5 μM 24 h has no effect on alpha tubulin acetylation 17447750
GM15850 Function Assay 5 μM 12 h has no effect on FXN mRNA expression 16921367
GM15850 Kinase Assay 2.5 μM 96 h does not inhibit HDAC assessed as increase in histone H4 lysine 16 acetylation of FXN gene 16921367
GM15850 Kinase Assay 2.5 μM 96 h does not inhibit HDAC assessed as increase in histone H4 lysine 8 acetylation of FXN gene 16921367
GM15850 Kinase Assay 2.5 μM 96 h does not inhibit HDAC assessed as increase in histone H3 lysine 9 acetylation of FXN gene 16921367
GM15850 Kinase Assay 2.5 μM 96 h does not inhibit HDAC assessed as increase in histone H4 lysine 12 acetylation of FXN gene 16921367
GM15850 Kinase Assay 2.5 μM 96 h does not inhibit HDAC assessed as increase in histone H4 lysine 5 acetylation of FXN gene 16921367
GM15850 Kinase Assay 2.5 μM 96 h does not inhibit HDAC assessed as increase in histone H3 lysine 14 acetylation of FXN gene 16921367
Jurkat Cytotoxic Assay 100 μM 72 h GI50=0.9 μM 24900743
AsPC1 Growth Inhibition Assay 30 μM 48 h IC50=3.66 μM 24185378
HL60 Kinase Assay 5 μM 24 h Inhibition of HDAC 23707260
HGC27 Growth Inhibition Assay 5 μM 72 h IC50=5.4 μM 23707260
GBC-SD Growth Inhibition Assay 5 μM 72 h IC50=14.8 μM 23707260
MEF Cytotoxic Assay 10 μM 72 h IC50=4.4 μM 23570542
HS68 Cytotoxic Assay 10 μM 72 h IC50=4.6 μM 23570542
MDA-MB-231 Kinase Assay 1 μM 24 h Inhibition of HDAC6 assessed as acetylation levels of tubulin 23493449
MDA-MB-231 Kinase Assay 10 μM 30 min Inhibition of HDAC2a 23493449
UO31 Growth Inhibition Assay 6.2 μM 72 h GI50=0.5 μM 22435669
UACC62 Growth Inhibition Assay 6.2 μM 72 h GI50=0.4 μM 22435669
UACC257 Growth Inhibition Assay 6.2 μM 72 h GI50=0.5 μM 22435669
TK10 Growth Inhibition Assay 6.2 μM 72 h GI50=0.63 μM 22435669
T47D Growth Inhibition Assay 6.2 μM 72 h GI50=0.5 μM 22435669
SR Growth Inhibition Assay 6.2 μM 72 h GI50=0.4 μM 22435669
SNB75 Growth Inhibition Assay 6.2 μM 72 h GI50=0.79 μM 22435669
SNB19 Growth Inhibition Assay 6.2 μM 72 h GI50=0.63 μM 22435669
SN12C Growth Inhibition Assay 6.2 μM 72 h GI50=2 μM 22435669
SKOV3 Growth Inhibition Assay 6.2 μM 72 h GI50=1 μM 22435669
SK-MEL-5 Growth Inhibition Assay 6.2 μM 72 h GI50=0.63 μM 22435669
SK-MEL-28 Growth Inhibition Assay 6.2 μM 72 h GI50=1 μM 22435669
SK-MEL-2 Growth Inhibition Assay 6.2 μM 72 h GI50=1.3 μM 22435669
SF539 Growth Inhibition Assay 6.2 μM 72 h GI50=2 μM 22435669
SF295 Growth Inhibition Assay 6.2 μM 72 h GI50=1.6 μM 22435669
SF268 Growth Inhibition Assay 6.2 μM 72 h GI50=1.6 μM 22435669
RXF393 Growth Inhibition Assay 6.2 μM 72 h GI50=1.3 μM 22435669
OVCAR8 Growth Inhibition Assay 6.2 μM 72 h GI50=0.5 μM 22435669
OVCAR5 Growth Inhibition Assay 6.2 μM 72 h GI50=0.79 μM 22435669
OVCAR4 Growth Inhibition Assay 6.2 μM 72 h GI50=4 μM 22435669
OVCAR3 Growth Inhibition Assay 6.2 μM 72 h GI50=1.3 μM 22435669
NCI-H522 Growth Inhibition Assay 6.2 μM 72 h GI50=0.5 μM 22435669
NCI-H460 Growth Inhibition Assay 6.2 μM 72 h GI50=0.79 μM 22435669
NCI-H322M Growth Inhibition Assay 6.2 μM 72 h GI50=0.79 μM 22435669
NCI-H23 Growth Inhibition Assay 6.2 μM 72 h GI50=1 μM 22435669
NCI-ADR-RES Growth Inhibition Assay 6.2 μM 72 h GI50=0.16 μM 22435669
MOLT4 Growth Inhibition Assay 6.2 μM 72 h GI50=0.4 μM 22435669
MDA-MB-468 Growth Inhibition Assay 6.2 μM 72 h GI50=0.63 μM 22435669
MDA-MB-435 Growth Inhibition Assay 6.2 μM 72 h GI50=0.5 μM 22435669
MCF10A Growth Inhibition Assay 6.2 μM 48 h GI50=9.6 μM 22435669
MALME-3M Growth Inhibition Assay 6.2 μM 72 h GI50=0.32 μM 22435669
M14 Growth Inhibition Assay 6.2 μM 72 h GI50=1.3 μM 22435669
LOXIMVI Growth Inhibition Assay 6.2 μM 72 h GI50=1 μM 22435669
IGROV1 Growth Inhibition Assay 6.2 μM 72 h GI50=1.3 μM 22435669
HOP92 Growth Inhibition Assay 6.2 μM 72 h GI50=4 μM 22435669
HCT15 Growth Inhibition Assay 6.2 μM 72 h GI50=2.5 μM 22435669
EKVX Growth Inhibition Assay 6.2 μM 72 h GI50=1.3 μM 22435669
BT549 Growth Inhibition Assay 6.2 μM 72 h GI50=1.3 μM 22435669
ACHN Growth Inhibition Assay 6.2 μM 72 h GI50=1.3 μM 22435669
A549/ATCC Growth Inhibition Assay 6.2 μM 72 h GI50=1.6 μM 22435669
A498 Growth Inhibition Assay 6.2 μM 72 h GI50=1.6 μM 22435669
786-0 Growth Inhibition Assay 6.2 μM 72 h GI50=3.2 μM 22435669
DU145 Kinase Assay 5 μM 24 h Inhibition of HDAC assessed as histone H3 hyperacetylation 22260166
DU145 Kinase Assay 5 μM 24 h Inhibition of HDAC assessed as histone H4 acetylation 22260166
DU145 Kinase Assay 2.5 μM 24 h Inhibition of HDAC assessed as upregulation of p21waf1 protein expression 22260166
CFBE41o Function Assay 1 μM 24 h Restoration of CFTR deltaF508 mutant trafficking to cell surface as glycoforms 21984958
GM11272 Function Assay 100 nM 72 h Reactivation of MeCp2 mutant expression at 10 to 100 nM 21840716
U937 Kinase Assay 5 μM 15 min Inhibition of histone acetyltransferase assessed as increase of histone H3 acetylation level 21292492
U937 Kinase Assay 5 μM 24 h Inhibition of histone acetyltransferase assessed as increase of pan-acetylated histone H4 level 21292492
U937 Kinase Assay 5 μM 24 h Inhibition of histone acetyltransferase assessed as increase of acetylation of histone H3 at K18 21292492
U937 Kinase Assay 5 μM 24 h Inhibition of histone acetyltransferase assessed as increase of acetylation of histone H3 at K9 21292492
HCT116 Kinase Assay 30 μM 30 h Inhibition of HDAC1 assessed as induction of histone H3K9 acetylation 21080647
HCT116 Kinase Assay 30 μM 30 h Inhibition of HDAC6 assessed as induction of alpha-tubulin acetylation 21080647
MCR5-SV2 Growth Inhibition Assay 10 μM 72 h GI50=2.1 μM 21080647
LoVo Growth Inhibition Assay 10 μM 72 h GI50=1.7 μM 21080647
DU145 Growth Inhibition Assay 10 μM 72 h GI50=1.05 μM 21080647
COR-L23 Growth Inhibition Assay 10 μM 72 h GI50=1.1 μM 21080647
A549 Function Assay 5 μM 3 h Induction of autophagy in human A549 cells assessed as increase in LC3II 20855208
NB4 Kinase Assay 5 μM 24 h Inhibition of HDAC assessed as increase in histone H3 acetylation 20491440
NB4 Function Assay 5 μM 24 h Induction of p21WAF1/CIP1 expression 20491440
NB4 Kinase Assay 5 μM 24 h Inhibition of HDAC assessed as increase in acetylate tubulin level 20491440
NB4 Function Assay 5 μM 24 h Cell cycle arrest assessed as increase in accumulation at pre-G1 phase 20491440
SCC4 Function Assay 1 μM 5 min Agonist activity at VDR assessed as induction of CYP24 gene expression 20452225
SCC4 Kinase Assay 1 μM 24h Inhibition of HDAC assessed as increase in histone acetylation 20452225
SCC4 Kinase Assay 1 μM 24h Inhibition of HDAC assessed as increase in tubulin acetylation 20452225
COLO205 Kinase Assay 10 μM 24 h Inhibition of HDAC1 assessed as induction of histone H3 acetylation with IC50 of 2.2 μM 20451378
HepG2 Kinase Assay 5 μM 6h Induction of HDAC-mediated H3/H4 histone acetylation 20143840
HepG2 Kinase Assay 5 μM 6h Induction of HDAC-mediated alpha-tubulin acetylation 20143840
HepG2 Kinase Assay 5 μM 6h Induction of HDAC-mediated histone hyperacetylation 20143840
HepG2 Kinase Assay 5 μM 6h Induction of HDAC-mediated histone acetylation 20143840
Caco-2 Kinase Assay 0.316 nM to 31.6 μM 4 h Ex vivo inhibition of human HDAC6 20143840
Caco-2 Kinase Assay 6.32 nM to 632 μM 4 h Ex vivo inhibition of human HDAC7 with IC50 of 41 μM 20143840
Caco-2 Kinase Assay 6.32 nM to 632 μM 4 h Ex vivo inhibition of human HDAC5 with IC50 of 12.6 μM 20143840
Caco-2 Kinase Assay 0.316 nM to 31.6 μM 4 h Ex vivo inhibition of human HDAC3 with IC50 of 0.147 μM 20143840
Caco-2 Kinase Assay 0.316 nM to 31.6 μM 4 h Ex vivo inhibition of human HDAC1 with IC50 of 0.119 μM 20143840
Caco-2 Kinase Assay 5 μM 4 h Induction of HDAC-mediated histone acetylation IC50 of 0.037 μM 20143840
Caco-2 Growth Inhibition Assay 100 μM 48h IC50=8.1 μM 20143840
MUF Growth Inhibition Assay 100 μM 48 h Growth inhibition at 0.05 to 100 uM 20143840
BJ Growth Inhibition Assay 100 μM 48 h Growth inhibition at 0.05 to 100 uM 20143840
Primary bronchial epithelial cell Kinase Assay 1 μM 96 h Inhibition of HDAC7 assessed as increase in short circuit currents 19966789
Primary bronchial epithelial cell Kinase Assay 5 μM 24 h Inhibition of HDAC assessed as induction of mutant Fdelta508 CFTR protein apical surface localization 19966789
CFBE41o- Kinase Assay 5 μM 24 h Inhibition of HDAC7 assessed as correction of mutant Fdelta508 CFTR trafficking to cell surface as glycoform 19966789
CFBE41o- Kinase Assay 5 μM 24 h Inhibition of HDAC7 assessed as increase in stability of Fdelta508 CFTR protein 19966789
CFBE41o- Kinase Assay 5 μM 24 h Inhibition of HDAC7 assessed as increase in rate of maturation of CFTR protein to its glycoform 19966789
CFBE41o- Kinase Assay 1 μM 24 h Inhibition of HDAC7 assessed as increase in Fdelta508 CFTR protein trafficking 19966789
CFBE41o- Kinase Assay 1 μM 5 days Inhibition of HDAC7 assessed as increase in stabilization of Fdelta508 CFTR protein 19966789
Primary bronchial epithelial cell Kinase Assay 1 μM 24 h Inhibition of HDAC7 assessed as induction of mutant Fdelta508 CFTR protein apical surface localization 19966789
CFBE41o- Kinase Assay 1 μM 1 h Inhibition of HDAC assessed as increase in CFTR protein level 19966789
CFBE41o- Kinase Assay 5 μM 4 h Inhibition of HDAC assessed as increase in mutant Fdelta508 CFTR protein level 19966789
CFBE41o- Kinase Assay 5 μM 8 h Inhibition of HDAC assessed as hyperacetylation of histone H3 19966789
BHK Kinase Assay 5 μM 24 h Inhibition of HDAC7 expressed assessed as increase in plasma membrane Fdelta508 CFTR protein 19966789
SHSY5Y Cytotoxic Assay 10 μM 48 h IC50=2 μM 19344175
SHSY5Y Kinase Assay 10 μM 48 h Inhibition of HDAC with IC50 of 0.5 μM 19344175
S2 Kinase Assay 0.1-10 μM 1 h Inhibition of Plasmodium falciparum HDAC1 expressed with IC50 of 0.059 μM 19317450
IGROV1 Kinase Assay 10 μM 4 h Inhibition of HDAC6 assessed as alpha-tubulin acetylation 19084294
IGROV1 Kinase Assay 10 μM 4 h Inhibition of HDAC assessed as histone-H4 acetylation 19084294
IGROV1 Kinase Assay 5 μM 24 h Inhibition of HDAC assessed as p53 acetylation 19084294
HeLa Kinase Assay 2 μM 30 min Inhibition of HDAC2 in human HeLa cells with IC50 of 0.1 μM 19084294
HEK293 Function Assay 10 μM 24 h Activation of mouse Wnt3a signaling expressed 19022675
RAW264.7 Function Assay 2 μM 3.5 h Antimalarial activity against Plasmodium falciparum infected with IC50 of 0.11 μM 18644969
SU 86.86 Cytotoxic Assay 50 μM 72h IC50=1.3 μM 18494463
Panc 04.03 Cytotoxic Assay 50 μM 72h IC50=1.2 μM 18494463
Mia Paca2 Cytotoxic Assay 50 μM 72h IC50=1.1 μM 18494463
Hup T3 Cytotoxic Assay 50 μM 72h IC50=0.8 μM 18494463
Human microvascular epithelial cell Cytotoxic Assay 50 μM 72 h IC50=1.3 μM 18494463
HPDE6c7 Cytotoxic Assay 50 μM 72 h IC50=1.3 μM 18494463
HEK-TE Function Assay 5 μM 6h Increase in histone H3 acetylation 18434144
U937 Kinase Assay 5 μM 24 h Inhibition of human HDAC4 18381238
U937 Kinase Assay 5 μM 24 h Inhibition of human HDAC1 18381238
U937 Function Assay 5 μM 24 h Induction of granulocytic differentiation 18381238
U937 Function Assay 5 μM 24 h Induction of apoptosis 18381238
U937 Function Assay 5 μM 24 h Induction of p21 expression 18381238
U937 Function Assay 5 μM 24 h Induction of alpha tubulin hyperacetylation 18381238
U937 Function Assay 5 μM 24 h Induction of histone H4 hyperacetylation 18381238
MCF7 Function Assay 10 μM 8 h Induction of tubulin hyperacetylation 18269226
NUGC3 Growth Inhibition Assay 5 μM 24 h GI50=2.79 μM 17904843
HeLa Kinase Assay 10 μM 30 min Inhibition of recombinant HDAC1 with IC50 of 0.02 μM 17691763
PANC1 Function Assay 1 μM 24 h Increase in p27kip1 gene expression 17588744
PANC1 Function Assay 1 μM 24 h Increase in p21WAF1/CIP1 gene expression 17588744
ST14A Function Assay 5 nM 72 h Increase in E2F1 mRNA expression 17565993
ST14A Function Assay 5 nM 72 h Increase in REST/NRSF mRNA expression 17565993
RAW264.7 Function Assay 10 μM 24h Inhibition of LPS-stimulated NO production with IC50 of 1.88 μM 17477518
RAW264.7 Function Assay 10 μM 24h Inhibition of LPS-stimulated TNFalpha production with IC50 of 0.76 μM 17477518
U937 Function Assay 1 μM 24 h Effect on alpha tubulin acetylation 17447750
U937 Function Assay 5 μM 24 h Increase in histone H3 acetylation 17447750
U937 Function Assay 5 μM 24 h Cell cycle arrest by accumulation at S/G2/M phase 17004718
GM15850 Kinase Assay 2.5 μM 96 h Inhibition of HDAC assessed as increase in histone H4 lysine 16 acetylation of FXN gene 16921367
GM15850 Kinase Assay 2.5 μM 96 h Inhibition of HDAC assessed as increase in histone H4 lysine 8 acetylation of FXN gene 16921367
GM15850 Kinase Assay 2.5 μM 96 h Inhibition of HDAC assessed as increase in histone H3 lysine 9 acetylation of FXN gene 16921367
GM15850 Kinase Assay 2.5 μM 96 h Inhibition of HDAC assessed as increase in histone H4 lysine 12 acetylation of FXN gene 16921367
GM15850 Kinase Assay 2.5 μM 96 h Inhibition of HDAC assessed as increase in histone H4 lysine 5 acetylation of FXN gene 16921367
GM15850 Kinase Assay 2.5 μM 96 h Inhibition of HDAC assessed as increase in histone H3 lysine 14 acetylation of FXN gene 16921367
ARP1 Function Assay 2 μM 6 h Induction of P21WAF1 gene expression 14734806
Friend leukemic cell Growth Inhibition Assay 50 μM 72 h IC50=0.99 μM 12109913
NUGC3 Growth Inhibition Assay 10 μM GI=2.94 μM 23163332
CFBE41o Kinase Assay 5 μM Down regulation of HDAC7 at 0.2 to 5 uM 21984958
PANC1 Growth Inhibition Assay 1 μM IC50=0.45 μM 17588744
HEK293 Growth Inhibition Assay 72 h GI50=13 μM 24900500
HL60 Growth Inhibition Assay 72 h GI50=0.93 μM 24900500
TSGH Cytotoxic Assay 12 h IC50=2.09 μM 24766560
MKN45 Cytotoxic Assay 12 h IC50=1.25 μM 24766560
MONE1 Cytotoxic Assay 12 h IC50=1.18 μM 24766560
H460 Cytotoxic Assay 12 h IC50=0.82 μM 24766560
KB Cytotoxic Assay 12 h IC50=0.75 μM 24766560
HT-29 Cytotoxic Assay 12 h IC50=0.72 μM 24766560
HSC3 Cytotoxic Assay 12 h IC50=0.71 μM 24766560
HEL Growth Inhibition Assay 48 h IC50=0.49 μM 24694055
KG1 Growth Inhibition Assay 48 h IC50=1.15 μM 24525003
Jurkat E6.1 Kinase Assay 2 h Inhibition of HDAC4 with IC50 of 0.04 μM 24261862
MDA-MB-435 Growth Inhibition Assay 48 h GI=0.88 μM 24119555
MCF7 Growth Inhibition Assay 48 h GI=0.45 μM 24119555
MDA-MB-231 Growth Inhibition Assay 48 h IC50=0.16 μM 24095016
Hs578T Cytotoxic Assay 48 h GI=4.83 μM 24015327
KM12 Cytotoxic Assay 48 h GI=1.88 μM 24015327
U251 Cytotoxic Assay 48 h GI=1.53 μM 24015327
SW620 Cytotoxic Assay 48 h GI=0.54 μM 24015327
NCI60 Cytotoxic Assay 48 h GI=0.53 μM 24015327
Vero Growth Inhibition Assay 72 h IC50=0.9 μM 23786452
High5 Kinase Assay 24 h Inhibition of human recombinant HDAC3 with IC50 of 0.17 μM 23602523
High5 Kinase Assay 24 h Inhibition of human recombinant HDAC1 with IC50 of 0.12 μM 23602523
High5 Kinase Assay 24 h Inhibition of human recombinant HDAC6 with IC50 of 0.09 μM 23602523
ES2 Growth Inhibition Assay 48 h IC50=12.7 μM 23493449
MDA-MB-231 CisR Kinase Assay 18 h Inhibition of HDAC with IC50 of 0.61 μM 23252603
MDA-MB-231 sens Kinase Assay 18 h Inhibition of HDAC with IC50 of 0.61 μM 23252603
KYSE-510 sens Kinase Assay 18 h Inhibition of HDAC with IC50 of 0.7 μM 23252603
KYSE-510 CisR Kinase Assay 18 h Inhibition of HDAC with IC50 of 0.59 μM 23252603
CAL27 CisR Kinase Assay 18 h Inhibition of HDAC with IC50 of 0.61 μM 23252603
CAL27 sens Kinase Assay 18 h Inhibition of HDAC with IC50 of 0.36 μM 23252603
A2780 CisR Kinase Assay 18 h Inhibition of HDAC with IC50 of 0.44 μM 23252603
SMMC7721 Growth Inhibition Assay 72 h GI90=20 μM 23061376
SKHEP1 Growth Inhibition Assay 72 h GI90=17 μM 23061376
SGC7901 Growth Inhibition Assay 72 h GI90=9.4 μM 23061376
MGC803 Growth Inhibition Assay 72 h GI90=10.8 μM 23061376
BGC823 Growth Inhibition Assay 72 h GI90=7.5 μM 23061376
Bel7404 Growth Inhibition Assay 72 h GI90=18 μM 23061376
Bel7402 Growth Inhibition Assay 72 h GI90=17 μM 23061376
BE(2)-C Growth Inhibition Assay 72 h IC70=2 μM 22932316
Hep3B Growth Inhibition Assay 48 h GI50=0.69 μM 22439863
Hep3B Growth Inhibition Assay 48 h GI50=1.21 μM 21712146
COLO205 Growth Inhibition Assay 96 h IC50=2.12 μM 21634430
A2780 Growth Inhibition Assay 96 h IC50=1.62 μM 21634430
SKOV3 Cytotoxic Assay 72 h Cytotoxicity against human SKOV3 cells overexpressing HER2 with IC50 of 2.2 μM 21080629
SKBR3 Cytotoxic Assay 72 h Cytotoxicity against human SKBR3 cells overexpressing HER2 with IC50 of 2.6 μM 21080629
Sf21 Kinase Assay 3 h Inhibition of Flag tagged human recombinant HDAC8 expressed with IC50 of 1.2 μM 21080629
HeLa Cytotoxic Assay 72 h Cytotoxicity against human HeLa cells overexpressing HDAC with IC50 of 1.5 μM 21080629
CAL27 Cytotoxic Assay 72 h Cytotoxicity against human CAL27 cells overexpressing EGFR with IC50 of 3.2 μM 21080629
A549 Cytotoxic Assay 72 h Cytotoxicity against human A549 cells overexpressing HDAC with IC50 of 1.8 μM 21080629
A431 Cytotoxic Assay 72 h Cytotoxicity against human A431 cells overexpressing EGFR with IC50 of 4.2 μM 21080629
U937 Growth Inhibition Assay 72 h GI50=0.39 μM 20884208
HUT78 Growth Inhibition Assay 72 h GI50=0.3 μM 20884208
SKHEP1 Growth Inhibition Assay 72 h IC50=3.46 μM 20143778
SCC25 Growth Inhibition Assay 72 h IC50=1.93 μM 20143778
SCC15 Growth Inhibition Assay 72 h IC50=2.49 μM 20143778
NCI-H358 Growth Inhibition Assay 72 h IC50=2.5 μM 20143778
NCI-H2122 Growth Inhibition Assay 72 h IC50=7.5 μM 20143778
LNCAP Growth Inhibition Assay 72 h IC50=0.58 μM 20143778
HCC827 Growth Inhibition Assay 72 h IC50=1.8 μM 20143778
Capan1 Growth Inhibition Assay 72 h IC50=7.3 μM 20143778
CAL27 Growth Inhibition Assay 72 h IC50=3.72 μM 20143778
BxPC3 Growth Inhibition Assay 72 h IC50=2.7 μM 20143778
HeLa Growth Inhibition Assay 72 h IC50=0.46 μM 19441846
SNB78 Growth Inhibition Assay 48 h GI50=16 μM 19419205
HBC5 Growth Inhibition Assay 48 h GI50=17 μM 19419205
DMS114 Growth Inhibition Assay 48 h GI50=2.9 μM 19419205
SKMES1 Cytotoxic Assay 72 h IC50=2.42 μM 19093884
NCI-H69 Cytotoxic Assay 72 h IC50=2.06 μM 19093884
HeLa Kinase Assay 15 min Inhibition of HDAC8 from nuclear extract with IC50 of 1.86 μM 19093884
HeLa Kinase Assay 15 min Inhibition of HDAC6 from nuclear extract with IC50 of 0.0855 μM 19093884
T24 Kinase Assay 3 h Induction of alpha tubulin acetylation with EC50 of 0.25 μM 19084395
T24 Kinase Assay 3 h Induction of histone H3 acetylation with EC50 of 0.12 μM 19084395
IGROV1 Growth Inhibition Assay 72 h IC50=2.2 μM 19084294
HCT116 Growth Inhibition Assay 72h IC50=0.31 μM 19084294
NB4 48h IC50=0.6 μM 18723349
HeLa Kinase Assay 2 h Inhibition of nuclear HDAC with IC50 of 0.083 μM 18558669
HEK293 Kinase Assay 3 h Inhibition of recombinant HDAC6 expression with IC50 of 0.019 μM 18558669
Human renal epithelial cell Growth Inhibition Assay 72 h IC50=14 μM 18370373
HeLa Growth Inhibition Assay 72 h IC50=0.46 μM 18370373
G401 Growth Inhibition Assay 72 h IC50=1 μM 18370373
HEK293 Kinase Assay 1 h Inhibition of HDAC3 with IC50 of 0.057 μM 18308563
HEK293 Kinase Assay 1 h Inhibition of HDAC1 with IC50 of 0.03 μM 18308563
U87MG Cytotoxic Assay 72 h IC50=11 μM 17691763
SK-OV-3 Cytotoxic Assay 72 h IC50=2.2 μM 17691763
Saos2 Cytotoxic Assay 72 h IC50=2.3 μM 17691763
RKOp21 Cytotoxic Assay 72 h IC50=1.76 μM 17691763
Hec-1-A Cytotoxic Assay 72 h IC50=1 μM 17691763
EOL1 Cytotoxic Assay 72 h IC50=1 μM 17691763
CCRF-CEM Cytotoxic Assay 72 h IC50=0.8 μM 17691763
Cal27 Cytotoxic Assay 72 h IC50=3.2 μM 17691763
A431 Cytotoxic Assay 72 h IC50=4.2 μM 17691763
PC3 Growth Inhibition Assay 21 h GI50=0.71 μM 17662606
ACHN Growth Inhibition Assay 21 h GI50=0.65 μM 17662606
SC9 Growth Inhibition Assay 48 h IC50=0.606 μM 17507219
H661 Growth Inhibition Assay 48 h IC50=1 μM 17157009
NCI-H23 Growth Inhibition Assay 48 h GI50=0.92 μM 16723227
HCT15 Growth Inhibition Assay 48 h GI50=0.82 μM 16723227
CEM Kinase Assay 1 h Inhibition of HDAC with IC50 of 0.33 μM 16420064
St-4 Growth Inhibition Assay 48 h IC50=5.2 μM 15715470
SNB-78 Growth Inhibition Assay 48 h IC50=16 μM 15715470
RXF-631L Growth Inhibition Assay 48 h IC50=2 μM 15715470
NCI-H226 Growth Inhibition Assay 48 h IC50=2.6 μM 15715470
LOX-IMVI Growth Inhibition Assay 48 h IC50=1.3 μM 15715470
HeLa Kinase Assay 30 min Inhibitory concentration against histone deacetylase with IC50 of 0.28 μM 15603949
H1299 Growth Inhibition Assay 72 h IC50=7.24 μM 14521422
A20 Kinase Assay 1 h anti-HDAC1 activity with IC50 of 0.112 μM 11960489
K562 Kinase Assay 6 h Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) with IC50 of 0.01 μM 12419380
HT1080 Growth Inhibition Assay 72 h IC50=2.4 μM 12270175
H1299 Kinase Assay 20 min Inhibitory activity against HDAC enzyme with IC50 of 0.194 μM 14521422
ECC10 Growth Inhibition Assay IC50=945.87 nM SANGER
A427 Growth Inhibition Assay IC50=920.84 nM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=910.49 nM SANGER
SK-N-DZ Growth Inhibition Assay IC50=900.43 nM SANGER
KE-37 Growth Inhibition Assay IC50=894.62 nM SANGER
HH Growth Inhibition Assay IC50=894.12 nM SANGER
HGC-27 Growth Inhibition Assay IC50=872.34 nM SANGER
SW954 Growth Inhibition Assay IC50=863.16 nM SANGER
QIMR-WIL Growth Inhibition Assay IC50=862.03 nM SANGER
HSC-4 Growth Inhibition Assay IC50=846.51 nM SANGER
D-566MG Growth Inhibition Assay IC50=838.62 nM SANGER
P30-OHK Growth Inhibition Assay IC50=835.7 nM SANGER
EW-18 Growth Inhibition Assay IC50=832.96 nM SANGER
RS4-11 Growth Inhibition Assay IC50=832.45 nM SANGER
LU-139 Growth Inhibition Assay IC50=822.86 nM SANGER
ALL-PO Growth Inhibition Assay IC50=814.66 nM SANGER
RPMI-8866 Growth Inhibition Assay IC50=813.67 nM SANGER
KU812 Growth Inhibition Assay IC50=813.1 nM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=809.44 nM SANGER
HEL Growth Inhibition Assay IC50=806.08 nM SANGER
SBC-1 Growth Inhibition Assay IC50=793.84 nM SANGER
TE-1 Growth Inhibition Assay IC50=791.1 nM SANGER
MOLT-4 Growth Inhibition Assay IC50=787.46 nM SANGER
KG-1 Growth Inhibition Assay IC50=775.45 nM SANGER
NB10 Growth Inhibition Assay IC50=751.92 nM SANGER
DU-4475 Growth Inhibition Assay IC50=751.91 nM SANGER
ATN-1 Growth Inhibition Assay IC50=740.28 nM SANGER
MOLT-13 Growth Inhibition Assay IC50=738.98 nM SANGER
NCI-H209 Growth Inhibition Assay IC50=729.9 nM SANGER
GOTO Growth Inhibition Assay IC50=729.12 nM SANGER
ES1 Growth Inhibition Assay IC50=724.4 nM SANGER
D-283MED Growth Inhibition Assay IC50=714.14 nM SANGER
D-423MG Growth Inhibition Assay IC50=706.89 nM SANGER
DOHH-2 Growth Inhibition Assay IC50=706.68 nM SANGER
NB14 Growth Inhibition Assay IC50=696.95 nM SANGER
RPMI-8226 Growth Inhibition Assay IC50=678.18 nM SANGER
MV-4-11 Growth Inhibition Assay IC50=659.1 nM SANGER
A4-Fuk Growth Inhibition Assay IC50=644.91 nM SANGER
CHL-1 Growth Inhibition Assay IC50=642.08 nM SANGER
DB Growth Inhibition Assay IC50=598.57 nM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=596.51 nM SANGER
CTV-1 Growth Inhibition Assay IC50=581.56 nM SANGER
OVCAR-5 Growth Inhibition Assay IC50=576.11 nM SANGER
KY821 Growth Inhibition Assay IC50=563.25 nM SANGER
NCI-H720 Growth Inhibition Assay IC50=560.18 nM SANGER
NKM-1 Growth Inhibition Assay IC50=544.27 nM SANGER
HD-MY-Z Growth Inhibition Assay IC50=538.13 nM SANGER
CTB-1 Growth Inhibition Assay IC50=537.92 nM SANGER
BE-13 Growth Inhibition Assay IC50=526.96 nM SANGER
ES8 Growth Inhibition Assay IC50=523.53 nM SANGER
L-363 Growth Inhibition Assay IC50=503.1 nM SANGER
BCPAP Growth Inhibition Assay IC50=501.42 nM SANGER
697 Growth Inhibition Assay IC50=473.41 nM SANGER
C2BBe1 Growth Inhibition Assay IC50=472.19 nM SANGER
CHP-212 Growth Inhibition Assay IC50=457.53 nM SANGER
EoL-1-cell Growth Inhibition Assay IC50=45425 nM SANGER
NB69 Growth Inhibition Assay IC50=411.71 nM SANGER
A3-KAW Growth Inhibition Assay IC50=400.59 nM SANGER
NB7 Growth Inhibition Assay IC50=345.74 nM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=294.53 nM SANGER
NEC8 Growth Inhibition Assay IC50=289.38 nM SANGER
PA-1 Growth Inhibition Assay IC50=286.26 nM SANGER
H9 Growth Inhibition Assay IC50=255.04 nM SANGER
BHT-101 Growth Inhibition Assay IC50=244.18 nM SANGER
KARPAS-45 Growth Inhibition Assay IC50=173.89 nM SANGER
KASUMI-1 Growth Inhibition Assay IC50=99.17 nM SANGER
K562 Kinase Assay does not inhibit HDAC 23591111
K562 Growth Inhibition Assay IC50=0.645 μM 23644210
HCT116 Growth Inhibition Assay IC50=0.757 μM 23644210
A549 Growth Inhibition Assay IC50=1.079 μM 23644210
BGC823 Growth Inhibition Assay GI50=3.09 μM 23601706
NUGC3 Growth Inhibition Assay GI50=2.94 μM 20850971
St4 Growth Inhibition Assay EC50=5.2 μM 18247554
SQ20B Growth Inhibition Assay IC50=3 μM 18247554
SNB78 Growth Inhibition Assay EC50=16 μM 18247554
SKBR3 Growth Inhibition Assay IC50=0.8 μM 18247554
HT1080 Growth Inhibition Assay IC50=0.0024 μM 18247554
HepG2 Growth Inhibition Assay IC50=0.0006 μM 18247554
CCD1059SK Growth Inhibition Assay IC50=43.5 μM 18247554
PT45 Growth Inhibition Assay IC50=4 μM 17588744
EW-1 Growth Inhibition Assay IC50=947.26 nM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=949.12 nM SANGER
HCC2218 Growth Inhibition Assay IC50=958.48 nM SANGER
HAL-01 Growth Inhibition Assay IC50=968.04 nM SANGER
RD Growth Inhibition Assay IC50=974.45 nM SANGER
SK-N-AS Growth Inhibition Assay IC50=988.1 nM SANGER
ML-2 Growth Inhibition Assay IC50=1.00407 μM SANGER
MEL-HO Growth Inhibition Assay IC50=1.00582 μM SANGER
MS-1 Growth Inhibition Assay IC50=1.00617 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=1.02331 μM SANGER
8505C Growth Inhibition Assay IC50=1.02331 μM SANGER
MN-60 Growth Inhibition Assay IC50=1.0268 μM SANGER
SAS Growth Inhibition Assay IC50=1.04081 μM SANGER
EFM-19 Growth Inhibition Assay IC50=1.04879 μM SANGER
Ca9-22 Growth Inhibition Assay IC50=1.05107 μM SANGER
NBsusSR Growth Inhibition Assay IC50=1.05166 μM SANGER
NB13 Growth Inhibition Assay IC50=1.05501 μM SANGER
SF295 Growth Inhibition Assay IC50=1.06624 μM SANGER
U-2-OS Growth Inhibition Assay IC50=1.07911 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=1.08291 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=1.09422 μM SANGER
RCM-1 Growth Inhibition Assay IC50=1.12102 μM SANGER
MC116 Growth Inhibition Assay IC50=1.13621 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=1.15406 μM SANGER
EW-3 Growth Inhibition Assay IC50=1.17212 μM SANGER
HCT-116 Growth Inhibition Assay IC50=1.1775 μM SANGER
MC-IXC Growth Inhibition Assay IC50=1.17881 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=1.18312 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=1.19108 μM SANGER
NB5 Growth Inhibition Assay IC50=1.19856 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50=1.23464 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=1.23835 μM SANGER
EFO-27 Growth Inhibition Assay IC50=1.25043 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=1.28329 μM SANGER
SW620 Growth Inhibition Assay IC50=1.29018 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=1.29797 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=1.31761 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=1.32477 μM SANGER
HCC1419 Growth Inhibition Assay IC50=1.34027 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=1.34112 μM SANGER
DEL Growth Inhibition Assay IC50=1.35162 μM SANGER
LXF-289 Growth Inhibition Assay IC50=1.3524 μM SANGER
EW-11 Growth Inhibition Assay IC50=1.36026 μM SANGER
KP-4 Growth Inhibition Assay IC50=1.37085 μM SANGER
NOS-1 Growth Inhibition Assay IC50=1.41194 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=1.41693 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=1.43945 μM SANGER
ES5 Growth Inhibition Assay IC50=1.443 μM SANGER
HuO9 Growth Inhibition Assay IC50=1.45362 μM SANGER
COLO-684 Growth Inhibition Assay IC50=1.46118 μM SANGER
EW-24 Growth Inhibition Assay IC50=1.46531 μM SANGER
BV-173 Growth Inhibition Assay IC50=1.47291 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=1.48536 μM SANGER
HuP-T4 Growth Inhibition Assay IC50=1.493 μM SANGER
TYK-nu Growth Inhibition Assay IC50=1.49851 μM SANGER
YH-13 Growth Inhibition Assay IC50=1.49894 μM SANGER
H4 Growth Inhibition Assay IC50=1.50912 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50=1.54477 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=1.54645 μM SANGER
ES7 Growth Inhibition Assay IC50=1.54773 μM SANGER
COR-L88 Growth Inhibition Assay IC50=1.56424 μM SANGER
TI-73 Growth Inhibition Assay IC50=1.5906 μM SANGER
RT-112 Growth Inhibition Assay IC50=1.59284 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=1.59385 μM SANGER
HC-1 Growth Inhibition Assay IC50=1.59866 μM SANGER
HT55 Growth Inhibition Assay IC50=1.65131 μM SANGER
IA-LM Growth Inhibition Assay IC50=1.69278 μM SANGER
EM-2 Growth Inhibition Assay IC50=1.70014 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=1.70435 μM SANGER
CAL-27 Growth Inhibition Assay IC50=1.70621 μM SANGER
COLO-800 Growth Inhibition Assay IC50=1.71179 μM SANGER
HCE-T Growth Inhibition Assay IC50=1.715 μM SANGER
CAMA-1 Growth Inhibition Assay IC50=1.71971 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=1.7211 μM SANGER
NH-12 Growth Inhibition Assay IC50=1.72691 μM SANGER
TCCSUP Growth Inhibition Assay IC50=1.72829 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=1.73157 μM SANGER
EW-16 Growth Inhibition Assay IC50=1.74107 μM SANGER
SNU-423 Growth Inhibition Assay IC50=1.75827 μM SANGER
Daoy Growth Inhibition Assay IC50=1.76319 μM SANGER
ES4 Growth Inhibition Assay IC50=1.78741 μM SANGER
PFSK-1 Growth Inhibition Assay IC50=1.8037 μM SANGER
ES3 Growth Inhibition Assay IC50=1.82681 μM SANGER
ONS-76 Growth Inhibition Assay IC50=1.82897 μM SANGER
JVM-3 Growth Inhibition Assay IC50=1.85451 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=1.87151 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=1.88197 μM SANGER
HN Growth Inhibition Assay IC50=1.88725 μM SANGER
HT Growth Inhibition Assay IC50=1.88947 μM SANGER
LoVo Growth Inhibition Assay IC50=1.8981 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=1.89946 μM SANGER
NB6 Growth Inhibition Assay IC50=1.91298 μM SANGER
EW-22 Growth Inhibition Assay IC50=1.92887 μM SANGER
ES6 Growth Inhibition Assay IC50=1.93631 μM SANGER
SCC-15 Growth Inhibition Assay IC50=1.93819 μM SANGER
HL-60 Growth Inhibition Assay IC50=1.93902 μM SANGER
human HOP-92 Growth Inhibition Assay IC50=1.94065 μM SANGER
SW626 Growth Inhibition Assay IC50=1.94899 μM SANGER
HEC-1 Growth Inhibition Assay IC50=1.9536 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=1.98231 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=1.99493 μM SANGER
A101D Growth Inhibition Assay IC50=2.20303 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=2.04599 μM SANGER
SBC-5 Growth Inhibition Assay IC50=2.06147 μM SANGER
HOS Growth Inhibition Assay IC50=2.07653 μM SANGER
K5 Growth Inhibition Assay IC50=2.07811 μM SANGER
HLE Growth Inhibition Assay IC50=2.08529 μM SANGER
HSC-2 Growth Inhibition Assay IC50=2.12898 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=2.14583 μM SANGER
DMS-273 Growth Inhibition Assay IC50=2.14837 μM SANGER
TE-8 Growth Inhibition Assay IC50=2.15765 μM SANGER
DSH1 Growth Inhibition Assay IC50=2.16398 μM SANGER
CAL-51 Growth Inhibition Assay IC50=2.16699 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=2.16844 μM SANGER
GCT Growth Inhibition Assay IC50=2.1777 μM SANGER
SW948 Growth Inhibition Assay IC50=2.18456 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=2.19317 μM SANGER
C8166 Growth Inhibition Assay IC50=2.21334 μM SANGER
OC-314 Growth Inhibition Assay IC50=2.23259 μM SANGER
CAL-39 Growth Inhibition Assay IC50=2.23626 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=2.24275 μM SANGER
A673 Growth Inhibition Assay IC50=2.25862 μM SANGER
HTC-C3 Growth Inhibition Assay IC50=2.2685 μM SANGER
NCI-H1666 Growth Inhibition Assay IC50=2.28111 μM SANGER
PSN1 Growth Inhibition Assay IC50=2.28913 μM SANGER
GI-1 Growth Inhibition Assay IC50=2.30543 μM SANGER
HuH-7 Growth Inhibition Assay IC50=2.30637 μM SANGER
JAR Growth Inhibition Assay IC50=2.31987 μM SANGER
5637 Growth Inhibition Assay IC50=2.32129 μM SANGER
GB-1 Growth Inhibition Assay IC50=2.32335 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=2.32615 μM SANGER
OAW-42 Growth Inhibition Assay IC50=2.33416 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=2.33906 μM SANGER
RH-18 Growth Inhibition Assay IC50=2.35022 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=2.36725 μM SANGER
NB17 Growth Inhibition Assay IC50=2.38243 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50=2.41873 μM SANGER
SN12C Growth Inhibition Assay IC50=2.43214 μM SANGER
HSC-3 Growth Inhibition Assay IC50=2.44509 μM SANGER
GAMG Growth Inhibition Assay IC50=2.44561 μM SANGER
HT-1080 Growth Inhibition Assay IC50=2.44864 μM SANGER
A549 Growth Inhibition Assay IC50=2.44893 μM SANGER
KNS-62 Growth Inhibition Assay IC50=2.45061 μM SANGER
YKG-1 Growth Inhibition Assay IC50=2.45437 μM SANGER
LU-134-A Growth Inhibition Assay IC50=2.47008 μM SANGER
FADU Growth Inhibition Assay IC50=2.47162 μM SANGER
TGBC11TKB Growth Inhibition Assay IC50=2.47177 μM SANGER
HT-3 Growth Inhibition Assay IC50=2.49535 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50=2.50549 μM SANGER
Mo-T Growth Inhibition Assay IC50=2.50927 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=2.53043 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=2.53513 μM SANGER
NCI-H1048 Growth Inhibition Assay IC50=2.55025 μM SANGER
KOSC-2 Growth Inhibition Assay IC50=2.56076 μM SANGER
A431 Growth Inhibition Assay IC50=2.56335 μM SANGER
COR-L23 Growth Inhibition Assay IC50=2.58566 μM SANGER
MKN28 Growth Inhibition Assay IC50=2.59037 μM SANGER
22RV1 Growth Inhibition Assay IC50=2.59274 μM SANGER
ABC-1 Growth Inhibition Assay IC50=2.6046 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=2.60984 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=2.62185 μM SANGER
SCC-4 Growth Inhibition Assay IC50=2.63012 μM SANGER
NCI-H661 Growth Inhibition Assay IC50=2.64085 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50=2.64143 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=2.64426 μM SANGER
BPH-1 Growth Inhibition Assay IC50=2.6585 μM SANGER
M14 Growth Inhibition Assay IC50=2.66993 μM SANGER
G-402 Growth Inhibition Assay IC50=2.70451 μM SANGER
AsPC-1 Growth Inhibition Assay IC50=2.7117 μM SANGER
NB12 Growth Inhibition Assay IC50=2.7171 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=2.74391 μM SANGER
U-266 Growth Inhibition Assay IC50=2.77121 μM SANGER
AM-38 Growth Inhibition Assay IC50=2.77355 μM SANGER
PC-14 Growth Inhibition Assay IC50=2.8051 μM SANGER
EGI-1 Growth Inhibition Assay IC50=2.81743 μM SANGER
LS-411N Growth Inhibition Assay IC50=2.8233 μM SANGER
BFTC-905 Growth Inhibition Assay IC50=2.85523 μM SANGER
CaR-1 Growth Inhibition Assay IC50=2.86 μM SANGER
NCI-H292 Growth Inhibition Assay IC50=2.86596 μM SANGER
8305C Growth Inhibition Assay IC50=2.86645 μM SANGER
SNU-449 Growth Inhibition Assay IC50=2.89182 μM SANGER
LCLC-103H Growth Inhibition Assay IC50=2.90438 μM SANGER
SW1573 Growth Inhibition Assay IC50=2.96082 μM SANGER
MLMA Growth Inhibition Assay IC50=2.96717 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=3.00796 μM SANGER
RMG-I Growth Inhibition Assay IC50=3.02592 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=3.03314 μM SANGER
PC-3 Growth Inhibition Assay IC50=3.03874 μM SANGER
SF268 Growth Inhibition Assay IC50=3.04523 μM SANGER
NCI-H810 Growth Inhibition Assay IC50=3.04823 μM SANGER
MEG-01 Growth Inhibition Assay IC50=3.06164 μM SANGER
SW13 Growth Inhibition Assay IC50=3.07847 μM SANGER
RH-1 Growth Inhibition Assay IC50=3.10278 μM SANGER
GT3TKB Growth Inhibition Assay IC50=3.11283 μM SANGER
TK10 Growth Inhibition Assay IC50=3.13724 μM SANGER
T-24 Growth Inhibition Assay IC50=3.1507 μM SANGER
A498 Growth Inhibition Assay IC50=3.20871 μM SANGER
GR-ST Growth Inhibition Assay IC50=3.22139 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=3.22398 μM SANGER
T47D Growth Inhibition Assay IC50=3.23627 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50=3.24644 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=3.26153 μM SANGER
HT-29 Growth Inhibition Assay IC50=3.26614 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=3.29511 μM SANGER
SW756 Growth Inhibition Assay IC50=3.29629 μM SANGER
RKO Growth Inhibition Assay IC50=3.30757 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50=3.33018 μM SANGER
DJM-1 Growth Inhibition Assay IC50=3.37674 μM SANGER
L-428 Growth Inhibition Assay IC50=3.40045 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50=3.41312 μM SANGER
Ca-Ski Growth Inhibition Assay IC50=3.4543 μM SANGER
639-V Growth Inhibition Assay IC50=3.46057 μM SANGER
SW1116 Growth Inhibition Assay IC50=3.46269 μM SANGER
DMS-114 Growth Inhibition Assay IC50=3.47066 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=3.47681 μM SANGER
COLO-829 Growth Inhibition Assay IC50=3.50073 μM SANGER
J82 Growth Inhibition Assay IC50=3.5057 μM SANGER
EW-13 Growth Inhibition Assay IC50=3.5251 μM SANGER
RXF393 Growth Inhibition Assay IC50=3.53294 μM SANGER
CAL-62 Growth Inhibition Assay IC50=3.54514 μM SANGER
OCUB-M Growth Inhibition Assay IC50=3.54665 μM SANGER
BT-474 Growth Inhibition Assay IC50=3.6331 μM SANGER
KYSE-180 Growth Inhibition Assay IC50=3.63372 μM SANGER
NCI-H650 Growth Inhibition Assay IC50=3.64287 μM SANGER
Detroit562 Growth Inhibition Assay IC50=3.65022 μM SANGER
SW48 Growth Inhibition Assay IC50=3.65657 μM SANGER
KYSE-450 Growth Inhibition Assay IC50=3.68582 μM SANGER
KYSE-510 Growth Inhibition Assay IC50=3.72181 μM SANGER
GP5d Growth Inhibition Assay IC50=3.7295 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50=3.74723 μM SANGER
Becker Growth Inhibition Assay IC50=3.75012 μM SANGER
WM-115 Growth Inhibition Assay IC50=3.78195 μM SANGER
G-401 Growth Inhibition Assay IC50=3.79085 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=3.79602 μM SANGER
SW982 Growth Inhibition Assay IC50=3.80551 μM SANGER
D-263MG Growth Inhibition Assay IC50=3.82051 μM SANGER
KM-H2 Growth Inhibition Assay IC50=3.82624 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=3.82841 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=3.84488 μM SANGER
LS-123 Growth Inhibition Assay IC50=3.87909 μM SANGER
CAKI-1 Growth Inhibition Assay IC50=3.89052 μM SANGER
MEL-JUSO Growth Inhibition Assay IC50=3.89153 μM SANGER
HCE-4 Growth Inhibition Assay IC50=3.91663 μM SANGER
TE-10 Growth Inhibition Assay IC50=3.9201 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=3.92889 μM SANGER
ETK-1 Growth Inhibition Assay IC50=3.94635 μM SANGER
A2780 Growth Inhibition Assay IC50=4.05966 μM SANGER
LU-65 Growth Inhibition Assay IC50=4.07633 μM SANGER
BHY Growth Inhibition Assay IC50=4.12495 μM SANGER
COR-L105 Growth Inhibition Assay IC50=4.13051 μM SANGER
CAL-12T Growth Inhibition Assay IC50=4.13103 μM SANGER
SCH Growth Inhibition Assay IC50=4.15743 μM SANGER
CW-2 Growth Inhibition Assay IC50=4.19001 μM SANGER
HCC1806 Growth Inhibition Assay IC50=4.20312 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=4.20927 μM SANGER
T98G Growth Inhibition Assay IC50=4.22157 μM SANGER
CAL-54 Growth Inhibition Assay IC50=4.22381 μM SANGER
CAL-33 Growth Inhibition Assay IC50=4.23064 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=4.24769 μM SANGER
NUGC-3 Growth Inhibition Assay IC50=4.25505 μM SANGER
DOK Growth Inhibition Assay IC50=4.26593 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=4.26859 μM SANGER
KYSE-70 Growth Inhibition Assay IC50=4.2934 μM SANGER
A204 Growth Inhibition Assay IC50=4.35803 μM SANGER
SCC-25 Growth Inhibition Assay IC50=4.35819 μM SANGER
EPLC-272H Growth Inhibition Assay IC50=4.3895 μM SANGER
CAL-120 Growth Inhibition Assay IC50=4.38992 μM SANGER
LS-513 Growth Inhibition Assay IC50=4.42198 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50=4.42382 μM SANGER
ESS-1 Growth Inhibition Assay IC50=4.42724 μM SANGER
GMS-10 Growth Inhibition Assay IC50=4.42819 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=4.50868 μM SANGER
HMV-II Growth Inhibition Assay IC50=4.5173 μM SANGER
COLO-741 Growth Inhibition Assay IC50=4.55994 μM SANGER
MKN45 Growth Inhibition Assay IC50=4.57732 μM SANGER
OAW-28 Growth Inhibition Assay IC50=4.58398 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=4.65238 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=4.70243 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=4.72273 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50=4.76107 μM SANGER
GCIY Growth Inhibition Assay IC50=4.77424 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=4.77655 μM SANGER
SW962 Growth Inhibition Assay IC50=4.78011 μM SANGER
NCI-H630 Growth Inhibition Assay IC50=4.78081 μM SANGER
786-0 Growth Inhibition Assay IC50=4.78773 μM SANGER
FTC-133 Growth Inhibition Assay IC50=4.79263 μM SANGER
BT-20 Growth Inhibition Assay IC50=4.79429 μM SANGER
Mewo Growth Inhibition Assay IC50=4.81747 μM SANGER
SW780 Growth Inhibition Assay IC50=4.85766 μM SANGER
OE33 Growth Inhibition Assay IC50=4.87713 μM SANGER
HCC1569 Growth Inhibition Assay IC50=4.88458 μM SANGER
TE-6 Growth Inhibition Assay IC50=4.93977 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=4.94421 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50=4.99962 μM SANGER
MCF7 Growth Inhibition Assay IC50=5.00738 μM SANGER
UACC-257 Growth Inhibition Assay IC50=5.02845 μM SANGER
SW1088 Growth Inhibition Assay IC50=5.02944 μM SANGER
A704 Growth Inhibition Assay IC50=5.0306 μM SANGER
A2058 Growth Inhibition Assay IC50=5.05908 μM SANGER
Calu-3 Growth Inhibition Assay IC50=5.06452 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=5.06903 μM SANGER
AU565 Growth Inhibition Assay IC50=5.09702 μM SANGER
DMS-79 Growth Inhibition Assay IC50=5.13883 μM SANGER
DK-MG Growth Inhibition Assay IC50=5.18438 μM SANGER
HuCCT1 Growth Inhibition Assay IC50=5.23856 μM SANGER
HT-144 Growth Inhibition Assay IC50=5.24987 μM SANGER
M059J Growth Inhibition Assay IC50=5.2576 μM SANGER
COLO-792 Growth Inhibition Assay IC50=5.26356 μM SANGER
SF539 Growth Inhibition Assay IC50=5.26632 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=5.27751 μM SANGER
NCI-H1703 Growth Inhibition Assay IC50=5.35826 μM SANGER
SW837 Growth Inhibition Assay IC50=5.37878 μM SANGER
U251 Growth Inhibition Assay IC50=5.39096 μM SANGER
SW1710 Growth Inhibition Assay IC50=5.41554 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=5.46335 μM SANGER
RVH-421 Growth Inhibition Assay IC50=5.49908 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50=5.62651 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=5.64041 μM SANGER
KYSE-270 Growth Inhibition Assay IC50=5.66031 μM SANGER
COLO-668 Growth Inhibition Assay IC50=5.7132 μM SANGER
LN-405 Growth Inhibition Assay IC50=5.73085 μM SANGER
HT-1376 Growth Inhibition Assay IC50=5.78052 μM SANGER
769-P Growth Inhibition Assay IC50=5.86718 μM SANGER
HuP-T3 Growth Inhibition Assay IC50=5.88677 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=5.92139 μM SANGER
MKN7 Growth Inhibition Assay IC50=5.988 μM SANGER
KS-1 Growth Inhibition Assay IC50=5.98836 μM SANGER
647-V Growth Inhibition Assay IC50=5.99148 μM SANGER
COLO-679 Growth Inhibition Assay IC50=6.00255 μM SANGER
AN3-CA Growth Inhibition Assay IC50=6.03441 μM SANGER
C32 Growth Inhibition Assay IC50=6.13034 μM SANGER
KM12 Growth Inhibition Assay IC50=6.24099 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=6.26152 μM SANGER
KYSE-410 Growth Inhibition Assay IC50=6.30645 μM SANGER
HPAF-II Growth Inhibition Assay IC50=6.3548 μM SANGER
LAN-6 Growth Inhibition Assay IC50=6.49631 μM SANGER
LU-99A Growth Inhibition Assay IC50=6.55989 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=6.56347 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=6.72233 μM SANGER
SW900 Growth Inhibition Assay IC50=6.76221 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=6.80403 μM SANGER
OMC-1 Growth Inhibition Assay IC50=6.85402 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=6.89669 μM SANGER
TE-9 Growth Inhibition Assay IC50=6.89847 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50=6.91226 μM SANGER
BFTC-909 Growth Inhibition Assay IC50=7.00641 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=7.02159 μM SANGER
TE-5 Growth Inhibition Assay IC50=7.02881 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50=7.05427 μM SANGER
SHP-77 Growth Inhibition Assay IC50=7.13952 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50=7.14072 μM SANGER
TE-11 Growth Inhibition Assay IC50=7.15184 μM SANGER
EKVX Growth Inhibition Assay IC50=7.19267 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50=7.21133 μM SANGER
C3A Growth Inhibition Assay IC50=7.3452 μM SANGER
CFPAC-1 Growth Inhibition Assay IC50=7.36222 μM SANGER
MG-63 Growth Inhibition Assay IC50=7.41849 μM SANGER
KYSE-140 Growth Inhibition Assay IC50=7.44061 μM SANGER
MPP-89 Growth Inhibition Assay IC50=7.59729 μM SANGER
COLO-824 Growth Inhibition Assay IC50=7.72863 μM SANGER
SiHa Growth Inhibition Assay IC50=7.83707 μM SANGER
SNU-387 Growth Inhibition Assay IC50=7.85347 μM SANGER
A172 Growth Inhibition Assay IC50=7.86172 μM SANGER
COLO-680N Growth Inhibition Assay IC50=7.9173 μM SANGER
HCC1395 Growth Inhibition Assay IC50=8.05452 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=8.05963 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=8.21937 μM SANGER
S-117 Growth Inhibition Assay IC50=8.25353 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=8.25781 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50=8.37047 μM SANGER
KALS-1 Growth Inhibition Assay IC50=8.50928 μM SANGER
LS-1034 Growth Inhibition Assay IC50=8.57437 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=8.73535 μM SANGER
OE19 Growth Inhibition Assay IC50=8.76262 μM SANGER
D-502MG Growth Inhibition Assay IC50=8.76994 μM SANGER
JEG-3 Growth Inhibition Assay IC50=8.78618 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=8.87565 μM SANGER
ME-180 Growth Inhibition Assay IC50=9.06725 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=9.10532 μM SANGER
HCC2998 Growth Inhibition Assay IC50=9.13681 μM SANGER
ACHN Growth Inhibition Assay IC50=9.24975 μM SANGER
D-392MG Growth Inhibition Assay IC50=9.25715 μM SANGER
no-11 Growth Inhibition Assay IC50=9.26028 μM SANGER
KLE Growth Inhibition Assay IC50=9.32232 μM SANGER
Calu-6 Growth Inhibition Assay IC50=9.37528 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=9.45171 μM SANGER
SW684 Growth Inhibition Assay IC50=9.46116 μM SANGER
SH-4 Growth Inhibition Assay IC50=9.49364 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=9.51644 μM SANGER
Saos-2 Growth Inhibition Assay IC50=9.52195 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50=9.67352 μM SANGER
SCC-9 Growth Inhibition Assay IC50=9.71816 μM SANGER
MFE-280 Growth Inhibition Assay IC50=9.72785 μM SANGER
BEN Growth Inhibition Assay IC50=9.82159 μM SANGER
CP50-MEL-B Growth Inhibition Assay IC50=9.92432 μM SANGER
SK-MEL-28 Growth Inhibition Assay IC50=10.0193 μM SANGER
NCI-H2452 Growth Inhibition Assay IC50=10.16 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=10.178 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50=10.1882 μM SANGER
A375 Growth Inhibition Assay IC50=10.2452 μM SANGER
HCC38 Growth Inhibition Assay IC50=10.322 μM SANGER
LK-2 Growth Inhibition Assay IC50=10.4208 μM SANGER
SF126 Growth Inhibition Assay IC50=10.4727 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=10.7838 μM SANGER
ACN Growth Inhibition Assay IC50=10.8679 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=10.8711 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=10.8746 μM SANGER
KYSE-150 Growth Inhibition Assay IC50=11.0387 μM SANGER
D-247MG Growth Inhibition Assay IC50=11.1009 μM SANGER
BxPC-3 Growth Inhibition Assay IC50=11.3747 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=11.4079 μM SANGER
CAS-1 Growth Inhibition Assay IC50=11.4109 μM SANGER
no-10 Growth Inhibition Assay IC50=12.1217 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50=12.2036 μM SANGER
KGN Growth Inhibition Assay IC50=12.2901 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=12.3956 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50=12.5816 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=13.0649 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50=13.4399 μM SANGER
H-EMC-SS Growth Inhibition Assay IC50=13.9104 μM SANGER
SW1783 Growth Inhibition Assay IC50=14.2391 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=14.419 μM SANGER
HCC70 Growth Inhibition Assay IC50=14.4233 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=14.7045 μM SANGER
KYSE-520 Growth Inhibition Assay IC50=14.927 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=14.9539 μM SANGER
SNB75 Growth Inhibition Assay IC50=15.0729 μM SANGER
SW872 Growth Inhibition Assay IC50=15.2218 μM SANGER
U031 Growth Inhibition Assay IC50=15.8028 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=15.8359 μM SANGER
NCI-H441 Growth Inhibition Assay IC50=16.0039 μM SANGER
TE-12 Growth Inhibition Assay IC50=16.1873 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50=16.573 μM SANGER
KNS-42 Growth Inhibition Assay IC50=16.6589 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=17.4201 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=17.9345 μM SANGER
K-562 Growth Inhibition Assay IC50=18.6317 μM SANGER
A388 Growth Inhibition Assay IC50=19.0303 μM SANGER
ZR-75-30 Growth Inhibition Assay IC50=19.0968 μM SANGER
LU-135 Growth Inhibition Assay IC50=19.2636 μM SANGER
NCI-H2029 Growth Inhibition Assay IC50=19.6021 μM SANGER
HT-1197 Growth Inhibition Assay IC50=19.9227 μM SANGER
IGR-1 Growth Inhibition Assay IC50=20.3117 μM SANGER
U-87-MG Growth Inhibition Assay IC50=20.6413 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=20.7501 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=21.2829 μM SANGER
NCI-H520 Growth Inhibition Assay IC50=22.7611 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50=23.0718 μM SANGER
UACC-893 Growth Inhibition Assay IC50=23.1038 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50=23.2674 μM SANGER
U-118-MG Growth Inhibition Assay IC50=23.7217 μM SANGER
NCI-H596 Growth Inhibition Assay IC50=23.9055 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=24.6759 μM SANGER
SW1417 Growth Inhibition Assay IC50=25.2498 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=26.4288 μM SANGER
COLO-678 Growth Inhibition Assay IC50=27.4919 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=28.126 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=30.1924 μM SANGER
HCC1954 Growth Inhibition Assay IC50=31.3666 μM SANGER
GAK Growth Inhibition Assay IC50=32.2616 μM SANGER
YAPC Growth Inhibition Assay IC50=33.7648 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50=34.3605 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=36.3022 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=37.0529 μM SANGER
D-336MG Growth Inhibition Assay IC50=41.8442 μM SANGER
UACC-62 Growth Inhibition Assay IC50=42.5505 μM SANGER
C-33-A Growth Inhibition Assay IC50=45.3256 μM SANGER
HCC1937 Growth Inhibition Assay IC50=47.1958 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=47.2287 μM SANGER
NCI-H727 Growth Inhibition Assay IC50=47.2451 μM SANGER
NY Growth Inhibition Assay IC50=49.3908 μM SANGER
NCI-H2291 Growth Inhibition Assay IC50=49.8301 μM SANGER
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生物活性

產(chǎn)品描述 Vorinostat (SAHA)是一種HDAC抑制劑，無細胞試驗中IC50為~10 nM。Vorinostat 會抑制高效的HPV-18 DNA擴增。
特性 Vorinostat是廣譜HDAC活性抑制劑，抑制I和II類酶 。
靶點
HDAC [1]
(Cell-free assay)
~10 nM
體外研究(In Vitro)
體外研究活性

Vorinostat是小分子量（<300）線性肟酸，抑制HDAC活性，包括乙?；M蛋白和非組蛋白的積累，抑制培養(yǎng)細胞的增殖，且抑制腫瘤生長。Vorinostat通過結(jié)合到酶的活性位點而抑制 HDAC活性。Vorinostat 抑制多種轉(zhuǎn)化細胞增殖（包括 淋巴瘤，多發(fā)性骨髓瘤，白血病，和非小細胞肺癌），與對照組相比抑制生長達50% 時的濃度為0.5 到10μM。Vorinostat作用于淋巴瘤和白血病細胞，包括 Burkitt, B-細胞急性淋巴細胞白血病 (B-ALL), MCL, DLBCL, ATL和T-細胞，不同程度抑制細胞增殖。除了抑制轉(zhuǎn)化細胞增殖, Vorinostat 也抑制正常細胞增殖，通過比較Vorinostat 作用于一組細胞系–正常人非纖維細胞(WI-38)和 SV40巨大T抗原轉(zhuǎn)化WI-38(VA-13細胞)而得到證明。Vorinostat 抑制兩種類型細胞增殖，這種作用存在劑量依賴性。但發(fā)現(xiàn)Vorinostat 對轉(zhuǎn)化細胞具有選擇毒性，包括使腫瘤細胞死亡，而對正常細胞只起抑制作用，不會使其死亡。[1] Genistein 和Vorinostat 聯(lián)用效果比5-aza和Vorinostat 聯(lián)用作用于誘導細胞死亡有效很多。Genistein和Vorinostat聯(lián)用作用于ARCaP-E使增殖降低 80 %，作用于ARCaP-M細胞，增殖降低60 %以上。Genistein和Vorinostat 聯(lián)用抑制細胞增殖具有協(xié)同效應。作用于ARCaP-E 細胞(820個基因 誘導和1046個基因抑制) ARCaP-M 細胞，Vorinostat比Genistein 影響更多基因。[2] Vorinostat作用于腫瘤細胞表面，提高Fas蛋白水平，這種作用存在劑量依賴性，且按0.75 μM劑量處理，提高達到一個穩(wěn)定水平。[3] Vorinostat 抑制腫瘤細胞生長，包括NB4, H460 和HCT-116，IC50分別為0.7μM, 3.4μM和1.2 μM。[4]
激酶實驗 組蛋白去乙?；富钚詼y定
為了進行 HDAC 實驗24 × 104 dpm 乙醇溶液(1 mCi/ml)中提供的sup>3H-醋酸鈉鹽標記的組蛋白H4等份樣, 加到每個試管中，試管中含懸浮在25 μL實驗buffer(100 mM Tris-HCl pH 8, 2mM EDTA)中的200 μg全部HeLa細胞裂解液進行免疫沉淀獲得的HDAC。加入不同濃度Vorinostat，在30oC下溫育90分鐘。加入20 μL 終止緩沖液(0.5 N HCl, 0.08 M AcOH)終止反應。加入0.8 mL TBME提取釋放放入氚醋酸鹽。在8,000 × g 轉(zhuǎn)速下離心5分鐘，600 μL 有機相(上相) 轉(zhuǎn)移到包含3 mL閃爍液的閃爍瓶中。
細胞實驗 細胞系 NB4, NCI-H460和HCT-116腫瘤細胞系
濃度 0 μM - 0.1 μM
孵育時間 48小時
方法

NB4, NCI-H460和HCT-116腫瘤細胞系生長在200 µL 96孔板中，約10%匯合，生長24小時后，覆蓋孔中。使用多種濃度 Vorinostat或溶劑處理腫瘤細胞24小時。處理后，沖洗實驗板，移除Vorinostat，溫育48小時。使用sulphorodamine B 實驗測定Vorinostat處理后存活細胞的分數(shù)。
實驗圖片 檢測方法 檢測指標 實驗圖片 PMID
Western blot Ac-Histone H4 / Ac-Histone H3 phospho-CDK1 phospho-Cdc25c / Cdc25c Cyclin B1 c-Myc / c-Raf / Akt / Cyclin D1 / CDK4 p-eIF2α / ATF4 / CHOP p21 21598070
Immunofluorescence HDAC1 / CK19 Nrf2 α-SMA Ac-STAT3 / IGF2 29917299
Growth inhibition assay Cell apoptosis Cell viability 19440035
ELISA IGF2 IL-13 / IL-10 / IL-5 M-CSF MMP-9 27086926
體內(nèi)研究(In Vivo)
體內(nèi)研究活性

Decitabine和Vorinostat都具有使腫瘤衰退的功能。然而, Decitabine 和 Vorinostat 聯(lián)用使腫瘤衰退的效果更強。沒有任何處理時,在野生型和Fasgld 小鼠中在肺腫瘤負擔方面觀察不到明顯的區(qū)別。然而, Decitabine 和Vorinostat聯(lián)用處理野生型小鼠，使腫瘤衰退比處理 Fasgld小鼠效果高很多。 Decitabine和Vorinostat使結(jié)腸癌細胞對FasL調(diào)節(jié)的腫瘤衰退敏感。低劑量Decitabine和Vorinostat處理，沒有明顯的肝臟毒性。[3]
動物實驗 Animal Models 植入CWR22腫瘤細胞的雄性BALB/c裸鼠
Dosages 25, 50, and 100 mg/kg/day
Administration 腹腔注射
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05700630 Withdrawn
HIV-1-infection|ART|Cd4+ Lymphocyte Deficiency|Lymphoid Tissue; Infection|Interleukin
Masonic Cancer Center University of Minnesota
 July 15 2024 Phase 1
NCT03022565 Withdrawn
Uveal Melanoma
University of Miami|University of Miami Sylvester Comprehensive Cancer Center
 January 2020 Early Phase 1
NCT03167437 Recruiting
Crohn''s Disease
National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC)
 October 30 2017 Phase 1|Phase 2
NCT03056495 Terminated
Alzheimer Disease
German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of G?ttingen
 September 28 2017 Phase 1

化學信息&溶解度

分子量 264.3 分子式

C14H20N2O3
CAS號 149647-78-9 SDF Download Vorinostat (SAHA) SDF
Smiles C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
儲存條件(自收到貨起)

體外溶解度
批次：

DMSO : 52 mg/mL ( (196.74 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Ethanol : 6.5 mg/mL (24.59 mM)

Water : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內(nèi)配方計算器

實驗計算

摩爾濃度計算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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常見問題及建議解決方法

問題 1:
What’s the recommendation about reconstitution of the compound for in vivo animal study?

回答：
We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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