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Entrectinib

別名: RXDX-101, NMS-E628 中文名稱：恩曲替尼

Entrectinib是一種口服生物可利用的泛-TrkA/B/C，ROS1 和 ALK 抑制劑，IC50范圍為 0.1~1.7 nM。Entrectinib (RXDX-101) 可誘導自噬。Phase 2。

Entrectinib Chemical Structure

Entrectinib Chemical Structure

CAS: 1108743-60-7

規(guī)格 價格 庫存 購買數(shù)量
10mM (1mL in DMSO) 1556.1 現(xiàn)貨
5mg 875.36 現(xiàn)貨
25mg 3073.41 現(xiàn)貨
100mg 6935.43 現(xiàn)貨
1g 12039.3 現(xiàn)貨
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Entrectinib相關(guān)產(chǎn)品

相關(guān)信號通路圖

Trk receptor Signaling Pathways

Trk receptor信號通路圖

細胞實驗數(shù)據(jù)示例

細胞系 實驗類型 給藥濃度 孵育時間 活性描述 文獻信息
KARPAS299 Function assay 60 mg/kg 12 hrs Ex vivo inhibition of NPM-ALK phosphorylation in SCID mouse xenografted with human KARPAS299 cells at 60 mg/kg, po administered as single dose measured after 12 hrs by Western blot analysis 27003761
KARPAS299 Function assay 60 mg/kg 18 hrs Ex vivo inhibition of NPM-ALK phosphorylation in SCID mouse xenografted with human KARPAS299 cells at 60 mg/kg, po administered as single dose measured after 18 hrs by Western blot analysis 27003761
KARPAS299 Function assay 60 mg/kg 12 hrs Ex vivo inhibition of NPM-ALK phosphorylation in SCID mouse xenografted with human KARPAS299 cells assessed as suppression of STAT3 phosphorylation at 60 mg/kg, po administered as single dose measured after 12 hrs by Western blot analysis 27003761
KARPAS299 Function assay 60 mg/kg 18 hrs In vivo inhibition of NPM-ALK phosphorylation in SCID mouse xenografted with human KARPAS299 cells assessed as suppression of STAT3 phosphorylation at 60 mg/kg, po administered as single dose measured after 18 hrs by Western blot analysis 27003761
NCI-H2228 Antitumor assay 30 to 60 mg/kg 10 days Antitumor activity against human NCI-H2228 cells xenografted in athymic nu/nu mouse assessed as tumor growth inhibition at 30 to 60 mg/kg, po bid administered for 10 days 27003761
NCI-H2228 Function assay 60 mg/kg 12 hrs Ex vivo inhibition of EML4-ALK phosphorylation in athymic nu/nu mouse xenografted with human NCI-H2228 cells at 60 mg/kg, po administered as single dose measured after 12 hrs by Western blot analysis 27003761
NCI-H2228 Function assay 60 mg/kg 18 hrs Ex vivo inhibition of EML4-ALK phosphorylation in athymic nu/nu mouse xenografted with human NCI-H2228 cells at 60 mg/kg, po administered as single dose measured after 18 hrs by Western blot analysis 27003761
NCI-H2228 Function assay 60 mg/kg 12 hrs Ex vivo inhibition of EML4-ALK phosphorylation in athymic nu/nu mouse xenografted with human NCI-H2228 cells assessed as suppression of AKT phosphorylation at 60 mg/kg, po administered as single dose measured after 12 hrs by Western blot analysis 27003761
NCI-H2228 Function assay 60 mg/kg 18 hrs Ex vivo inhibition of EML4-ALK phosphorylation in athymic nu/nu mouse xenografted with human NCI-H2228 cells assessed as suppression of AKT phosphorylation at 60 mg/kg, po administered as single dose measured after 18 hrs by Western blot analysis 27003761
KARPAS299 Antitumor assay 30 to 60 mg/kg 10 days Antitumor activity against human KARPAS299 cells xenografted in SCID mouse assessed as tumor growth inhibition at 30 to 60 mg/kg, po bid administered for 10 days 27003761
KARPAS299 Antitumor assay 30 to 60 mg/kg 10 days Antitumor activity against human KARPAS299 cells xenografted in SCID mouse assessed as tumor free cured mouse at 30 to 60 mg/kg, po bid administered for 10 days measured on day 90 27003761
BAF3 Function assay 72 hrs Inhibition of human TEL (336 residues) fused-ROS1 (1891 to 2347 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay, IC50 = 0.005 μM. 27003761
BAF3 Function assay 72 hrs Inhibition of human TEL (336 residues) fused-TRKC (454 to 825 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay, IC50 = 0.003 μM. 27003761
BAF3 Function assay 72 hrs Inhibition of human TEL (336 residues) fused-TRKA (440 to 796 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay, IC50 = 0.003 μM. 27003761
BAF3 Function assay 72 hrs Inhibition of human TEL (336 residues) fused-TRKB (455 to 822 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay, IC50 = 0.003 μM. 27003761
KM12 Antiproliferative assay 72 hrs Antiproliferative activity against human KM12 cells expressing TRKA protein incubated for 72 hrs by cell titer-glo assay, IC50 = 0.017 μM. 27003761
SU-DHL1 Antiproliferative assay 72 hrs Antiproliferative activity against human SU-DHL1 cells expressing ALK protein incubated for 72 hrs by cell titer-glo assay, IC50 = 0.024 μM. 27003761
BAF3 Function assay 72 hrs Inhibition of wild type EML4-ALK (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay, IC50 = 0.028 μM. 27003761
KARPAS299 Antiproliferative assay 72 hrs Antiproliferative activity against human KARPAS299 cells incubated for 72 hrs by cell titer-glo assay, IC50 = 0.031 μM. 27003761
SUP-M2 Antiproliferative assay 72 hrs Antiproliferative activity against human SUP-M2 cells expressing ALK protein incubated for 72 hrs by cell titer-glo assay, IC50 = 0.041 μM. 27003761
BAF3 Function assay 72 hrs Inhibition of EML4-ALK L1196M mutant (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay, IC50 = 0.067 μM. 27003761
NCI-H2228 Antiproliferative assay 72 hrs Antiproliferative activity against human NCI-H2228 cells expressing ALK protein incubated for 72 hrs by cell titer-glo assay, IC50 = 0.068 μM. 27003761
MV411 Antiproliferative assay 72 hrs Antiproliferative activity against human MV411 cells incubated for 72 hrs by cell titer-glo assay, IC50 = 0.081 μM. 27003761
SR786 Antiproliferative assay 72 hrs Antiproliferative activity against human SR786 cells expressing ALK protein incubated for 72 hrs by cell titer-glo assay, IC50 = 0.081 μM. 27003761
BAF3 Function assay 72 hrs Inhibition of EML4-ALK G1202R mutant (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay, IC50 = 0.897 μM. 27003761
BA/F3 Cytotoxicity assay 72 hrs Cytotoxicity against mouse IL-3 dependent BA/F3 cells incubated for 72 hrs by cell titer-glo assay, IC50 = 2.104 μM. 27003761
KM12 Function assay 2 hrs Inhibition of TPM3-TRKA phosphorylation in human KM12 cells at low concentration after 2 hrs by Western blot analysis 27003761
KM12 Function assay 2 hrs Inhibition of TPM3-TRKA phosphorylation in human KM12 cells assessed as suppression of MAPK phosphorylation at low concentration after 2 hrs by Western blot analysis 27003761
KM12 Function assay 2 hrs Inhibition of TPM3-TRKA phosphorylation in human KM12 cells assessed as suppression of PLCgamma1 phosphorylation at low concentration after 2 hrs by Western blot analysis 27003761
KM12 Function assay 2 hrs Inhibition of TPM3-TRKA phosphorylation in human KM12 cells assessed as suppression of AKT phosphorylation at low concentration after 2 hrs by Western blot analysis 27003761
KM12 Function assay 2 hrs Inhibition of TPM3-TRKA phosphorylation in human KM12 cells assessed as suppression of S6 phosphorylation at low concentration after 2 hrs by Western blot analysis 27003761
KARPAS299 Function assay 2 hrs Inhibition of NPM/ALK autophosphorylation in human KARPAS299 cells at very low concentration after 2 hrs by Western blot analysis 27003761
NCI-H2228 Function assay 2 hrs Inhibition of NPM/ALK autophosphorylation in human NCI-H2228 cells at very low concentration after 2 hrs by Western blot analysis 27003761
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生物活性

產(chǎn)品描述 Entrectinib是一種口服生物可利用的泛-TrkA/B/C，ROS1 和 ALK 抑制劑，IC50范圍為 0.1~1.7 nM。Entrectinib (RXDX-101) 可誘導自噬。Phase 2。
靶點
TrkA [1] TrkB [1] TrkC [1] ROS1 [1] ALK [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05770544 Recruiting
Solid Tumor|Haematological Malignancy|Malignancy|Malignant Neoplasm|Lymphoproliferative Disorders|Neoplasms by Histologic Type|Neoplasms by Site|Cancer|Brain Neoplasms|Melanoma|Glioma
Cancer Research UK|University of Manchester|University of Birmingham|Royal Marsden NHS Foundation Trust|Hoffmann-La Roche
 June 2024 Phase 2|Phase 3
NCT04551495 Recruiting
Invasive Lobular Breast Carcinoma|ER+ Breast Cancer|HER2-negative Breast Cancer
Jules Bordet Institute|Hoffmann-La Roche
 January 14 2021 Phase 2
NCT04226833 Completed
Hepatic Insufficiency
Hoffmann-La Roche
 February 11 2020 Phase 1
NCT03796013 Completed
Healthy Volunteers
Genentech Inc.
 January 10 2019 Phase 1

化學信息&溶解度

分子量 560.64 分子式

C31H34F2N6O2
CAS號 1108743-60-7 SDF Download Entrectinib SDF
Smiles CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6
儲存條件(自收到貨起)

體外溶解度
批次：

DMSO : 100 mg/mL ( (178.36 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Ethanol : 100 mg/mL (178.36 mM)

Water : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

 動物體內(nèi)配方計算器

實驗計算

摩爾濃度計算器

質(zhì)量 濃度 體積 分子量

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

mg/kg g μL 只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO % % Tween 80 % ddH2O
%DMSO %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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