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輕松掃碼查看產(chǎn)品文檔 | TCIMAIL No.197 已上新 | TCI試劑——品質(zhì)可靠，值得信賴
訂購方法？聯(lián)系方式：021-67121386 / Sales-CN@TCIchemicals.com

Maximum quantity allowed is 999

請選擇數(shù)量

CAS RN: 15687-27-1 | 產(chǎn)品編碼: I0415

Ibuprofen

純度/分析方法: >98.0%(GC)(T)

別名：

布洛芬
2-(4-異丁基苯基)丙酸
4-異丁基-α-甲基苯乙酸
2-(4-Isobutylphenyl)propionic Acid
4-Isobutyl-α-methylphenylacetic Acid

產(chǎn)品文檔：

規(guī)格	單價	上海	天津	日本*	庫存詳情
1G	￥80.00	一個工作日后發(fā)貨	一個工作日后從上海發(fā)貨	請聯(lián)系我們	查詢
5G	￥160.00	8	17	請聯(lián)系我們	查詢
25G	￥260.00	18	3	≥100	查詢
100G	￥460.00	9	1	15	查詢
500G	￥1,890.00	2	1	28	查詢

添加到您的購物車

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基本信息

產(chǎn)品編碼	I0415
純度/分析方法	>98.0%(GC)(T)
分子式/分子量	C__1__3H__1__8O__2 = 206.29
外觀與形狀（20°C）	固體
儲存溫度	室溫 (15°C以下陰涼干燥處)
CAS RN	15687-27-1
Reaxys-RN	2049713
PubChem物質(zhì)ID	87571768
SDBS (AIST Spectral DB)	10570
Merck Index (14)	4881
MDL編號	MFCD00010393

技術(shù)規(guī)格和文件 plus

技術(shù)規(guī)格

Appearance	White to Almost white powder to crystal
Purity(GC)	min. 98.0 %
Purity(Neutralization titration)	min. 98.0 %
Melting point	75.0 to 78.0 °C
Solubility in Methanol	almost transparency

物性（參考值）

熔點(diǎn)	76 °C
沸點(diǎn)	157 °C/4 mmHg
水溶性	不溶
在水中的溶解度	21 mg/l 25 °C

安全和法規(guī) plus

GHS

象形圖
信號詞	警告
危險性說明	H302 : 吞咽有害。 H361 : 懷疑對生育能力或胎兒造成傷害。
防范說明	P501 : 將內(nèi)裝物/容器送到批準(zhǔn)的廢物處理廠處理。 P270 : 使用本產(chǎn)品時不要進(jìn)食、飲水或吸煙。 P202 : 在閱讀并明了所有安全措施前切勿搬動。 P201 : 使用前取得專用說明。 P264 : 作業(yè)后徹底清洗皮膚。 P280 : 戴防護(hù)手套/穿防護(hù)服/戴防護(hù)眼罩/戴防護(hù)面具。 P308 + P313 : 如接觸到或有疑慮：求醫(yī)/就診。 P301 + P312 + P330 : 如誤吞咽：如感覺不適，呼叫急救中心/醫(yī)生。漱口。 P405 : 存放處須加鎖。

相關(guān)法規(guī)

RTECS#

MU6640000

運(yùn)輸信息

監(jiān)管條件代碼(*)

應(yīng)用實(shí)例?文獻(xiàn) plus

應(yīng)用

Ibuprofen: A Non-Selective Non-Steroidal Anti-Inflammatory Drug (NSAID)

Ibuprofen is a non-selective non-steroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which possesses analgesic and antipyretic activities. Ibuprofen is a racemic compound and the active enantiomer is (S)-(+)-ibuprofen [I0549] which works by inhibiting both the COX-1 and COX-2 enzymes and prostaglandin synthesis. NSAIDs also include ketoprofen [K0038], loxoprofen [L0244] and naproxen [M1021] among others. Resently, some studies have suggested that NSAIDs may reduce the risk of certain types of cancer and Alzheimer's disease. (The product is for research purpose only.)

References

Ibuprofen: pharmacology, efficacy and safety (a review)
- K. D. Rainsford, Inflammopharmacology 2009, 17, 275.
Enantioselective pharmacokinetics of ibuprofen and involved mechanisms (a review)
- H. Hao, G. Wang, J. Sun, Drug Metab. Rev. 2005, 37, 215.
Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy (a review)
- J. A. Mitchell, T. D. Warner, Br. J. Pharmacol. 1999, 128, 1121.
Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: A critical review of non-selective COX-2 blockade (a review)
- R. E. Harris, J. Beebe-Donk, H. Doss, D. B. Doss, Oncol. Rep. 2005, 13, 559.
NSAID and antioxidant prevention of Alzheimer's disease: Lessons from in vitro and animal models (a review)
- G. M. Cole, T. Morihara, G. P. Lim, F. Yang, A. Begum, S. A. Frautschy, Ann. N.Y. Acad. Sci. 2004, 1035, 68.
Resolution of enantiomers of ibuprofen by liquid chromatography: a review
- R. Bhushan, J. Martens, Biomed. Chromatogr. 1998, 12, 309.
Ibuprofen (a review on the methods of preparations, physical properties, stability, metabolism and pharmacokinetics and methods for the detection of ibuprofen)
- J. D. Higgins, T. P. Gilmor, S. A. Martellucci, R. D. Bruce, H. G. Brittain, Anal. Profiles Drug Subst. Excipients 2001, 27, 265.

應(yīng)用

Binding of Ibuprofen to Human Serum Albumin

Ibuprofen is known to have affinity for Human Serum Albumin (HSA) and to bind (interact) to drug binding site II on HSA. Those were confirmed using our ibuprofen with Surface Plasmon Resonance (SPR) and a method using fluorescent probes. 【SPR】Dose responses of ibuprofen to HSA were confirmed by SPR. Biacore, as a SPR biosensor, was used for the assay, according to the user’s guide of the instrument.

＜Assay condition＞ Sensor Chip: Series S Sensor Chip CM5, Immobilization: HAS (Amine Coupling method), Buffer : 5%DMSO in PBS. ＜Result＞ “Square wave” sensorgrams were exhibited at each concentration, and concentration dependent binding of ibuprofen to HSA was confirmed. 【Method using fluorescent probes】The drug biding site of ibuprofen was confirmed using fluorescent probes which bind to drug binding site on HSA. Dansylamide (DNSA) [D5405] was used as fluorescent probe for site I, and dansylglycine (DNSG) [D5406], BD140 [D4898] were used as fluorescent probes for site II, and then bindings to site I and site II were confirmed.

＜Assay condition＞ Buffer: 1 % DMSO in phosphate buffer (pH 7.2 - 7.5); HSA: 5 µM (DNSA), 20 µM (DNSG, BD140) (50 µL/well) (Fatty acid free HSA is recommended.); Ibuprofen: each concentration (50 µL/well); DNSA: 80 µM, DNSG: 20 µM, BD140: 20 µM (50 µL/well); Incubation: 20-25 °C for 30 min; Measurement: plate-reader with excitation = 365 nm and emission = 480 nm (DNSA, DNSG), with excitation = 365 nm and emission = 585 nm (BD140). ＜Result＞ As shown in upper diagram, inhibition against binding of dansylglycine and BD140 which are fluorescent probes for site II by ibuprofen was confirmed. And also, little or extremely weak inhibition against binding of dansylamide which is fluorescent probe for site I was confirmed. In these ways, our ibuprofen can be used for study of interaction with HSA. Also, DNSA [D5405], DNSG [D5406] and BD140 [D4898] can be used for study of drug binding site on HSA.