PLX 4032 - RG 7204 | Vemurafenib | RO 5185426

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1624

CAS [918504-65-1]

MF C23H18ClF2N3O3S
MW 489.92

Purity: 98%
Soluble in DMSO

PLX 4032

Description

Selective inhibitor of protein kinase, targeting B-Raf (V600E) (IC50: 44 nM); PLX4032 has been shown to cause programmed cell death in melanoma cell lines; a potential anti-tumor agent under clinical trials

G Bollag et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 2010, 467, 596–599.

PI Poulikakos et al. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010, 464, 427-430.

E Sala et al. BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to Different Responses in Melanoma and Thyroid Carcinoma Cells. Mol. Cancer Res. 2008, 6(5), 751-759.

Cell Signaling & Oncology MAPK EC 2.7.11.1 RAF

B-Raf protein kinase inhibitor

Chemical name

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

Parent CAS No.

[918504-65-1]

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Size	Unit Price	Stock
5 mg	$66.00	In Stock
25 mg	$132.00	In Stock

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PLX 4032 - RG 7204 | Vemurafenib | RO 5185426

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PLX 4032 - RG 7204 | Vemurafenib | RO 5185426

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Chemical name

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