CK 1827452 - Omecamtiv Mecarbil | CK-452

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1835

CAS [873697-71-3]

MF C20H24FN5O3
MW 401.43

Purity: 99%
Soluble in DMSO

CK 1827452

Description

Selective cardiac specific myosin activator; clinically tested for its role in the treatment of left ventricular systolic heart failure.

F Malik et al. The Selective Cardiac Myosin Activator, CK-1827452, a Calcium-Independent Inotrope, Increases Left Ventricular Systolic Function by Increasing Ejection Time Rather than the Velocity of Contraction. Circulation 2006, 114, 441.

JR Teerlink. A novel approach to improve cardiac performance: cardiac myosin activators. Heart Fail Rev. 2009, 14(4), 289–298.

RJ Solaro. CK-1827452, a sarcomere-directed cardiac myosin activator for acute and chronic heart disease. IDrugs. 2009 Apr;12(4):243-51.

Cardiovascular Cell Signaling & Oncology EC 3.6.4.1 ATPase (myosin)

Cardiac specific myosin ATPase activator

Chemical name

methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate

Parent CAS No.

[873697-71-3]

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5 mg	$126.50	In Stock
25 mg	$423.50	In Stock

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Size	Unit Price	Stock
2 x 5 mg	$198.00	In Stock
2 x 25 mg	$638.00	In Stock

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CK 1827452 - Omecamtiv Mecarbil | CK-452

Description

Chemical name

Parent CAS No.

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