99% purity available from supplier Axon Medchem, prime source of life science reagents for your research" />

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WP 1066

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2316

CAS [857064-38-1]

MF C17H14BrN3O
MW 356.22

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO and Ethanol

WP 1066

Description

Potent inhibitor of JAK2 and STAT3 activity (IC50 values 2.3 µM and 5.6 µM, respectively) that showed selective cytotoxicity toward malignant glioma U87-MG and U373-MG cells at much lower doses than its analogue AG 490 (Axon 1378). Furthermore, WP1066 selectively induces apoptosis in malignant glioma cells by downregulating antiapoptotic proteins (Bcl-XL, Mcl-1 and c-myc) and activating Bax, and significantly inhibited the growth of subcutaneous tumors generated from U87-MG cells in mice.

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10 mg $104.50 In Stock
50 mg $313.50 In Stock
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2 x 10 mg $154.00 In Stock
2 x 50 mg $484.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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