(S)-(+)-Rolipram

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1432

CAS [85416-73-5]

MF C16H21NO3
MW 275.34

Purity: 99%
Soluble in DMSO and Ethanol

(S)-(+)-Rolipram

Description

PDE4 inhibitor, less active S-enantiomer of Rolipram (Axon 1212) in comparison with the opposite (R)-(-)-Rolipram (Axon 1229).

HH Schneider et al. Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur. J. Pharmacol. 1986, 127(1-2), 105-15.

DE Griswold et al. Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation. 1993, 17(3), 333–44.

SJ Kanes et al. Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity. Neuroscience. 2006, 144, 239-46.

RW Chen et al. Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation. Neuroscience Letters. 2007, 418(2), 165–9.

Cell Signaling & Oncology CNS Pain & Inflammation EC 3.1.4.53 PDE

PDE4 inhibitor

Chemical name

(4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Parent CAS No.

[85416-73-5]

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10 mg	$126.50	In Stock
50 mg	$462.00	In Stock

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(S)-(+)-Rolipram

Description

Chemical name

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