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Axon 2453
CAS [709002-46-0]
MF C22H20N4OS2MW 420.55
SIRT2 inhibitor (IC50 value 0.14 µM) with in vivo activity, showing >1000 fold selectivity over other Class-I sirtuins SIRT1 and SIRT3. Application of SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1.
KEYWORDS: SIRT2 inhibitor | Axon 2453 | SirReal2 | 709002-46-0 | Histone | SIRT | Inhibitor | Sirtuin | tubulin | checkpoint protein | BubR1
2-(4,6-dimethylpyrimidin-2-ylthio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide
[709002-46-0]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
Download the Axon Ligands™ catalogue 2025 Spring Edition
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