LDN 57444

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2449

CAS [668467-91-2]

MF C17H11Cl3N2O3
MW 397.64

Purity: 99%
Soluble in DMSO

LDN 57444

Description

Reversible, competitive inhibitor of UCH-L1 (Ki value 0.40 μM; IC50 values 0.88 μM and 25 μM for UCH-L1 and UCH-L3 inhibition, respectively), that promotes proliferation of H1299 NSCLC cells and SH-SY5Y neuroblastoma cells. A usefull tool to study the role of UCH-L1 in Parkinson’s disease, cancer, and neuropathic pain.

Y. Liu et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol. 2003 Sep;10(9):837-46.

UCH-L1 inhibition involved in CREB dephosphorylation in hippocampal slices. M Xie et al. J Mol Neurosci. 2014 May;53(1):59-68.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology CNS Pain & Inflammation Ubiquitin EC 3.4.19.12 Deubiquitinase

Reversible, competitive inhibitor of UCH-L1 deubiquitinase

Chemical name

3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one

Parent CAS No.

[668467-91-2]

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Size	Unit Price	Stock
10 mg	$104.50	In Stock
50 mg	$368.50	In Stock

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LDN 57444

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成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

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LDN 57444

Description

Chemical name

Parent CAS No.

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