VX 680 - MK 0457 | Tozasertib

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1540

CAS [639089-54-6]

MF C23H28N8OS
MW 464.59

Purity: 98%
Soluble in DMSO

VX 680

Description

Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for aurora A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases

EA Harrington et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Medicine 10, 262 - 267 (2004)

GM Cheetham et al. Structural basis for potent inhibition of the aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680. Cancer Lett. 2007, 251, 323-329.

FJ Giles et al. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood 2007, 109, 500-502.

Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora

Aurora inhibitor (non-specific)

Chemical name

Cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)-pyrimidin-2 -ylsulfanyl]-phenyl}-amide

Parent CAS No.

[639089-54-6]

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10 mg	$66.00	In Stock
50 mg	$104.50	In Stock

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VX 680 - MK 0457 | Tozasertib

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VX 680 - MK 0457 | Tozasertib

Description

Chemical name

Parent CAS No.

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