Non-ATP-competitive inhibitor of Akt isoforms 1 and 2 (IC50 values 58 nM and 210 nM for Akt1 and Akt2, respectively). Moreover, the Akt inhibitor efficiently inhibits Ca2+/CaM-dependent protein kinase (CaMKIα) activity (IC50 value 3.99 μM) and prevents TCDD induced nuclear translocation of aryl hydrocarbon receptor (AhR) in MCF-7 cells. Akti-1/2 inhibitory effects towards CaMKIα and TCDD-induced EROD activity in function of Akti-1/2 concentrations were quite similar (IC50 ± SD, 3.99 ± 0.82 μM and 5.86 ± 1.85 μM, respectively).

KEYWORDS: Akt Inhibitor VIII | supplier | Akt inhibitor | Akti-1/2 | compound8 | inhibitorVIII | CAS [612847-09-3] | Phosphatidylinositol | Akt | PI3K | PKB | calcium | Ca2+/CaM-dependent protein kinase | CaMKIα | aryl hydrocarbon receptor | AhR | TCDD