AZD1080
Axon 2171
CAS [612487-72-6]
MF C19H18N4O2
MW 334.37
- Purity: 98%
- Soluble in DMSO
Description
Potent and selective inhibitor of Glycogen synthase kinase 3 (GSK-3), with Ki values of 6.9 nM and 31 nM for GSK-3α and GSK-3β respectively. In phase 1 clinical studies, AZD1080 inhibits tau phosphorylation in cells expressing human tau and in intact rat brain. Interestingly, subchronic but not acute administration with AZD1080 reverses MK-801-induced deficits, measured by long-term potentiation in hippocampal slices and in a cognitive test in mice.
Selective inhibitor of GSK-3α and GSK-3β
Chemical name
2-Hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile
Parent CAS No.
[612487-72-6]
Order
Size | Unit Price | Stock | |
---|---|---|---|
5 mg | $99.00 | In Stock | |
25 mg | $352.00 | In Stock |
Special Offers
Size | Unit Price | Stock | |
---|---|---|---|
2 x 5 mg | $154.00 | In Stock |
Need more? Bulk Inquiry