Apremilast - CC 10004

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1957

CAS [608141-41-9]

MF C22H24N2O7S
MW 460.50

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Apremilast

Description

Orally active inhibitor of phosphodiesterase-4 (PDE4); an investigational drug for ankylosing spondylitis, psoriasis, and psoriatic arthritis. Apremilast reduces TNF-α production from human synovial cells and significantly suppresses experimental arthritis

K Papp et al. Efficacy of apremilast in the treatment of moderate to severe psoriasis: a randomised controlled trial. Lancet, 2012, 380 (9843), 738-746.

P Schafer. Apremilast mechanism of action and application to psoriasis and psoriatic arthritis. Biochem. Pharmacol. 2012, 83 (12), 1583–1590.

FE McCann et al. Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Arthritis Res. Ther. 2010, 12(3), R107.

Cell Signaling & Oncology CNS Immunology Pain & Inflammation EC 3.1.4.53 PDE

PDE4 inhibitor

Chemical name

(S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

Parent CAS No.

[608141-41-9]

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Size	Unit Price	Stock
5 mg	$66.00	In Stock
25 mg	$198.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	$99.00	In Stock

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Apremilast - CC 10004

Description

Chemical name

Parent CAS No.

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