AZD6244 - ARRY 142886 | Selumetinib

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1516

CAS [606143-52-6]

MF C17H15BrClFN4O3
MW 457.68

Purity: 99%
Soluble in DMSO

AZD6244

Description

An orally active, highly potent and selective inhibitor of MEK 1/2 that has shown tumor-suppressive activity in a wide range of preclinical models. IC50 value to be 14 nM against purified MEK1

TC Yeh et al. Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor. Clin. Cancer Res. 2007, 13, 1576-1583.

BR Davies et al. AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases. Mol. Cancer Ther. 2007, 6(8), 2209-2019.

List of publications using AZD6244 - Selumetinib (Axon 1516) purchased from Axon Medchem

Cell Signaling & Oncology Stem Cell MAPK EC 2.7.12.2 MEK

MEK1 and MEK2 inhibitor

Chemical name

5-(4-bromo-2-chlorophenylamino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide

Parent CAS No.

[606143-52-6]

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5 mg	$66.00	In Stock
25 mg	$176.00	In Stock

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Size	Unit Price	Stock
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2 x 25 mg	$242.00	In Stock

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AZD6244 - ARRY 142886 | Selumetinib

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Parent CAS No.

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AZD6244 - ARRY 142886 | Selumetinib

Description

Chemical name

Parent CAS No.

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