Pifithrin-β - PFT-β | Z-2-035II

Based on 18 reference(s) in Google Scholar 8 10 18

Axon 3051

CAS [60477-34-1]

MF C16H16N2S
MW 268.38

Purity: 99%
Soluble in DMSO

Pifithrin-β

Description

Pifithrin-β is the condensation product of the p53 protein inhibitor Pifithrin-α (Axon 1871). Pifithrin-α is unstable in vitro and is rapidly converted to Pifithrin-β.

N Pietrancosta et al. Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4.

N Pietrancosta et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J Med Chem. 2006 Jun 15;49(12):3645-52.

MI Walton et al. An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines. Mol Cancer Ther. 2005 Sep;4(9):1369-77.

Apoptosis Cell Cycle Regulation Stem Cell p53 Transcription Factors DNA-damage Response Ubiquitin TF class 4.3.1

Inhibitor of p53 protein; Condensation product of Pifithrin-α

Chemical name

2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole

Parent CAS No.

[60477-34-1]

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Pifithrin-β - PFT-β | Z-2-035II

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Chemical name

Parent CAS No.

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