(±)-PH 797804 - rac-PH 797804

Based on 8 reference(s) in Google Scholar 8 10 8

Axon 2786

CAS [586379-66-0]

MF C22H19BrF2N2O3
MW 477.30

Purity: 99%
Soluble in DMSO and ethanol

(±)-PH 797804

Description

Similar to the (-)-atropisomer PH 797804 (Axon 1837), racemic (±)-PH 797804 is a potent, selective and metabolically stable inhibitor of p38 MAPK (IC50 values of 2.5 and 15 nM in p38α cascade and hPBMC TNF assays, respectively).

HR Hope et al. Anti-Inflammatory Properties of a Novel N-Phenyl Pyridinone Inhibitor of p38 Mitogen-Activated Protein Kinase: Preclinical-to-Clinical Translation. J. Pharmacol. Exp. Ther. 2009, 331(3), 882-895.

SR Selness et al. Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg. Med. Chem. Lett. 2011, 21(13), 4066-4071.

L Xing et al. Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate. ChemMedChem. 2012, 7(2), 273–280.

Cell Cycle Regulation MAPK (p38) MAPK EC 2.7.11.24

Inhibitor of p38α MAPK

Chemical name

3-(3-Bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide

Parent CAS No.

[586379-66-0]

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10 mg	$126.50	In Stock
50 mg	$456.50	In Stock

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(±)-PH 797804 - rac-PH 797804

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Parent CAS No.

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(±)-PH 797804 - rac-PH 797804

Description

Chemical name

Parent CAS No.

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