IC 87114

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2168

CAS [371242-69-2]

MF C22H19N7O
MW 397.43

Purity: 98%
Soluble in DMSO

IC 87114

Description

Potent and highly selective small molecule inhibitor of the PI3K p110δ isoform (IC50 values for PI3Kα, β, γ, and δ are >100, 75, 29, and 0.5 μM respectively). IC87114 potently inhibited PIP3 biosynthesis in neutrophils by 60–65% and at 1 μM, it inhibited neutrophil migration by 75% as compared with the control.IC 87114 reduced the infiltration of inflammatory cells into the pancreatic islets and, accordingly, delayed and reduced the loss of glucose homeostasis.

C. Sadhu et al. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J. Immunol. 2003, 170, 2647-2654.

D.P. Sutherlin et al. Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf. Bioorg. Med. Chem. Lett. 2012, 22, 4296-302.

Cell Signaling & Oncology Pain & Inflammation PI3K PI3K-Akt-mTOR EC 2.7.1.153

Potent and highly selective inhibitor of the PI3K p110δ

Chemical name

2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one

Parent CAS No.

[371242-69-2]

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5 mg	$93.50	In Stock
25 mg	$324.50	In Stock

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IC 87114

Description

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