C 646

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1781

CAS [328968-36-1]

MF C24H19N3O6
MW 445.42

Purity: 99%
Moderately soluble in DMSO

C 646

Description

Competitive p300/CBP histone acetyltransferase (HAT) inhibitor with a Ki of 400 nM; Selective versus other acetyltransferases

EM Bowers et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem. Biol. 2010, 17, 471-482. [onlne]

NY Crump et al. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A. 2011, 108(19), 7814-7819.

Cell Signaling & Oncology Epigenetics HAT EC 2.3.1.48

HAT inhibitor (p300/CBP selective)

Chemical name

4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

Parent CAS No.

[328968-36-1]

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2 mg	$66.00	In Stock
10 mg	$132.00	In Stock
50 mg	$462.00	In Stock

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C 646

Description

Chemical name

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