Unique specific activator of cytosolic Akt (PKB) with the potential to recapitulate the primary cellular function of Akt signaling in a hippocampal neuronal culture system and a mouse model for ischemic stroke, resulting in augmented neuronal survival. Paradoxically, SC 79 suppressed PH-Akt-GFP plasma membrane translocation.

Close analogue of HA 14-1 (Axon 2007), a Bcl-2 antagonist (IC50 value 9 µM).

KEYWORDS: SC 79 | supplier | Akt activator | SC79 |CAS [305834-79-1] | Phosphatidylinositol | Akt | Activator | PKB | cytosolic | phosphorylation | ischemia | neuronal death | stroke | Bcl-2 | HA14-1 | plecstrin homolog | translocation