Orally bioavailable and brain penetrant proneurogenic and neuroprotective compound that activates NAMPT (nicotinamide phosphoribosyltransferase). P7C3 exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis, and improves cognitive function in aged rats and increases neuronal survival in mouse models of Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS).

KEYWORDS: P7C3 | supplier | NAMPT activator | CAS [301353-96-8] | Nicotinamide D-ribonucleotide | nicotinamide phosphoribosyltransferase | orally bioavailable | brain penetrant | Parkinson's | amyotrophic lateral sclerosis | ALS | proneurogenic | neuroprotective | antidepressant | neurogenesis | cognitive function | neuronal survival