CDDO-Me - Bardoxolone methyl | RTA 402

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1772

CAS [218600-53-4]

MF C32H43NO4
MW 505.69

Purity: 98%
Soluble in DMSO

CDDO-Me

Description

Orally-available antioxidant inflammation modulator (AIM), being the most potent known inducer of the Nrf2 pathway; induces apoptosis of human tumor cells by disruption of redox balance and directly blocks IKKβ activity and thereby the NF-κB pathway

R Ahmad et al. Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179. J. Biol. Chem. 2006, 281, 35764-35769.

M Konopleva et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood 2002, 99(1), 326-335.

R Ahmad et al. Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation. Mol. Cancer Res. 2010, 8(7), 986-993.

MB Sporn et al. New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. J. Nat. Prod. 2011, 74(3), 537-545.

Apoptosis Cell Signaling & Oncology Immunology Pain & Inflammation Transcription Factors NF-κB EC 2.7.11.10 IKK

IKK-2 inhibitor; Inducer of the Nrf2 pathway

Chemical name

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

Parent CAS No.

[218600-53-4]

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Size	Unit Price	Stock
5 mg	$88.00	In Stock
25 mg	$264.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	$132.00	In Stock
2 x 25 mg	$396.00	In Stock

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CDDO-Me - Bardoxolone methyl | RTA 402

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Parent CAS No.

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成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

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CDDO-Me - Bardoxolone methyl | RTA 402

Description

Chemical name

Parent CAS No.

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