ML329 is an inhibitor of the MITF molecular pathway (IC50 value of 1.2 μM; TRPM-1 promoter activity) and showed specific activity against MITF-dependent cells (IC50 values of 0.1 and 0.7 μM in SK-MEL-5 and MALME-3M cell lines, respectively). ML329 also reduced the expression of the cell cycle regulator CDK2, and showed CDK1 inhibition (IC50 value of 0.5 μM).

KEYWORDS: ML329 | supplier | MITF inhibitor | CID 12387471 | ML 329 | ML-329 | CAS [19992-50-8] | DNA-RNA | MITF | Inhibitor | Transcription Factors | Microphthalmia-associated transcription factor | Melanoma