SD 169

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1357

CAS [1670-87-7]

MF C9H8N2O
MW 160.17

Purity: 99%
Soluble in DMSO and Ethanol

SD 169

Description

ATP-competitive, orally active inhibitor of p38α MAP kinase (IC50 = 3.2 nM); being 38 fold selective vs against p38β MAP kinase (IC50 = 122 nM) and no inhibitory activity against a panel of other kinases including p38γ MAP kinase, ERK2, JNK-1 and MAPKAPK-2.

S Medicherla et al. Preventive and Therapeutic Potential of p38α Selective MAPK Inhibitor in NOD Mice with Type 1 Diabetes. J. Pharmacol. Exp. Ther. 2006, 318, 99-107.

Robert R. Myers et al. Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp. Neurol. 2003, 184(2), 606-614.

J Yang et al. Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma. Leukemia, 2012, 26(9), 2114-2123.

List of publications using SD 169 (Axon 1357) purchased from Axon Medchem

Cell Signaling & Oncology Pain & Inflammation MAPK (p38) MAPK EC 2.7.11.24

MAPK inhibitor (p38α specific)

Chemical name

1H-Indole-5-carboxylic acid amide

Parent CAS No.

[1670-87-7]

Order

Size	Unit Price	Stock
5 mg	$66.00	In Stock
25 mg	$198.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	$99.00	In Stock
2 x 25 mg	$286.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1122	SL 327	MEK1 and MEK2 inhibitor	$88.00
1223	PD98059	MEK inhibitor	$88.00
1358	BIRB 796	MAPK inhibitor (p38 specific)	$71.50
1363	SB 203580	MAPK inhibitor (p38 specific)	$104.50
1364	SB 202190	MAPK inhibitor (p38 specific)	$104.50
1365	PD169316	MAPK inhibitor (p38 specific)	$104.50
1366	LY 294002	PI3K inhibitor	$77.00
1368	PD184352	MEK 1 inhibitor	$88.00
1393	Gefitinib	EGFR tyrosine kinase inhibitor	$77.00
1399	AZD7762 hydrochloride	CHK inhibitor	$66.00
1406	CP 101606 mesylate	NMDA NR2B antagonist	$93.50
1408	PD0325901	MEK1 and MEK2 inhibitor	$55.00
1409	KO 143	BCRP inhibitor	$66.00
1459	GDC 0879	B-Raf protein kinase inhibitor	$77.00
1461	Cediranib	VEGFR tyrosine kinase inhibitor	$77.00
1465	SB 203580 hydrochloride	MAPK inhibitor (p38 specific)	$77.00
1506	WZ 4002	EGFR kinase inhibitor (T790M specific)	$77.00
1516	AZD6244	MEK1 and MEK2 inhibitor	$66.00
1527	XAV939	Tankyrase (TNKS) inhibitor	$88.00
1545	AZ 628	B-Raf and C-Raf protein kinase inhibitor	$88.00
1603	Rolofylline	Adenosine A1 antagonist	$99.00
1613	MDV 3100	Androgen receptor (AR) antagonist	$77.00
1631	Vildagliptin	DPP4 inhibitor	$66.00
1644	Biphenyl-indanone A	Positive allosteric modulator (PAM) of mGluR2	$104.50
1646	Zaleplon	GABAA-α1 agonist	$77.00
1660	Crizotinib	c-MET Inhibitor; NPM-ALK inhibitor	$77.00
1671	SCIO 469	MAPK inhibitor (p38 specific)	$132.00
1678	Regorafenib	Multi-kinase RTK inhibitor	$77.00
1694	FR 180204	ERK inhibitor; AP-1 inhibitor	$104.50
1696	Quizartinib dihydrochloride	FLT3 inhibitor	$99.00
1697	BAY K 8644	Calcium (Ca2+) channel activator (L-type voltage-gated)	$104.50
1701	Shz-1	Stem cell differentiating agent; Nkx2.5 inducer	$104.50
1761	GSK 1120212	MEK1 and MEK2 inhibitor	$77.00
1772	CDDO-Me	IKK-2 inhibitor; Inducer of the Nrf2 pathway	$88.00
1779	WP 1130	Deubiquitinase Inhibitor	$104.50
1809	BIX 02189	MEK5 inhibitor; ERK5 inhibitor	$121.00
1811	VX 745	Inhibitor of p38α MAP kinase	$99.00
1822	N6022	Inhibitor of S-nitrosoglutathione reductase (GSNOR)	$99.00
1837	PH 797804	Inhibitor of p38α MAPK	$126.50
1846	XMD 8-92	BMK1 inhibitor; ERK5 inhibitor	$77.00
1865	Stemregenin 1	Aryl hydrocarbon receptor (AHR) antagonist	$115.50
1884	Alectinib	Orally available and selective ALK inhibitor	$77.00
1895	LY 2228820	Inhibitor of p38 MAPK	$115.50
1999	AZD8330	MEK 1 inhibitor	$115.50
2010	TDZD 8	Selective and non-ATP-competitive inhibitor of GSK-3β	$99.00
2018	CGI 1746	Inhibitor of Bruton's tyrosine kinase (BTK)	$55.00
2036	KY 02111	Canonical Wnt signaling pathway inhibitor	$88.00
2077	OG-L002 hydrochloride	Inhibitor of lysine specific demethylase 1 (LSD1 aka KDM1A)	$137.50
2084	SKL 2001	Wnt/β-catenin signaling pathway agonist or activator	$99.00
2287	Wnt-C59	Highly potent porcupine (Porcn) inhibitor	$82.50
2366	NG 25 trihydrochloride	Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK)	$82.50
2444	SB 706504	Selective p38 MAPK inhibitor that targets a subset of inflammatory macrophage genes.	$137.50
2520	U 0126	Non-competitive inhibitor of MEK1/2 and protects brain in stroke models	$99.00
2786	(±)-PH 797804	Inhibitor of p38α MAPK	$126.50
2856	BMS 582949	Inhibitor of p38α MAPK	$170.50
3183	SR-318	Highly potent and selective type-II p38 α/β inhibitor	$132.00
3440	MK2 inhibitor III	Potent and selective MK-2 inhibitor	$132.00
1621	XMD 8-92 trifluoroacetate	BMK1 inhibitor; ERK5 inhibitor	$77.00
3620	MAPK13 inhibitor compound 61	MAPK13 inhibitor (p38δ specific)	$154.00
4219	VX-702	Orally bioavailable p38 MAP kinase inhibitor	Inquire

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Customer Support

Customer Services

About Axon Medchem

Contact Us

SD 169

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Customer Support

Customer Services

About Axon Medchem

Contact Us

SD 169

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us