Potent inhibitor of 12-lipoxygenase (12-LOX) (IC50 value of 0.34 µM) which shows excellent selectivity against related enzymes (15-LOX-1, 5-LOX, 15-LOX-2, COX-1/-2). Besides, ML 355 exhibits a favourable in vitro ADME and in vivo PK pro?le with activity in disease relevant cell-based systems, such thrombosis (platelet aggregation and calcium mobilization), and diabetes (12-HETE reducing in β -cells).

KEYWORDS: ML 355 | supplier | Lipoxygenase inhibitor | ML355 | ML-355 | CAS [1532593-30-8] | Fatty acid (Arachidonic acid) | LOX | Inhibitor | Enzymes | Thrombosis | Diabetes