Torin 1

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1833

CAS [1222998-36-8]

MF C35H28F3N5O2
MW 607.62

Purity: 98%
Poorly soluble in DMSO

Torin 1

Description

Highly potent, selective and ATP-competitive mTOR inhibitor, with IC50 to be 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases

Q Liu et al. Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective mTOR Inhibitor for the Treatment of Cancer. J. Med. Chem. 2010, 53(19), 7146–7155.

Q Liu et al. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available (mTOR) inhibitor for treatment of cancer. J. Med. Chem. 2011, 54(5), 1473-1480.

Cell Signaling & Oncology mTOR PI3K-Akt-mTOR EC 2.7.11.1

mTOR inhibitor

Chemical name

1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one

Parent CAS No.

[1222998-36-8]

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25 mg	$330.00	In Stock

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Torin 1

Description

Chemical name

Parent CAS No.

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