Alpelisib - NVP-BYL719 | BYL-719

Based on 102 reference(s) in Google Scholar 8 10 102

Axon 2925

CAS [1217486-61-7]

MF C19H22F3N5O2S
MW 441.47

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

Alpelisib

Description

Alpelisib is a potent and selective PI3K α-isoform inhibitor with an IC50 value of 5 nM. Moreover, Alpelisib has shown good efficacy in inhibiting the growth of PI3K α-isoform driven tumors in animal xenograft models as well as good tolerability.

KEYWORDS: Alpelisib | supplier | PI3K inhibitor | NVP-BYL719 | BYL-719 | NVPBYL719 | BYL719 | BYL 719 | CAS [1217486-61-7] | CAS [1584128-91-5] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes

P Furet et al. Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3741-8.

Cell Signaling & Oncology PI3K PI3K-Akt-mTOR EC 2.7.1.153

PI3K inhibitor (p110-α specific)

Chemical name

(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide

Parent CAS No.

[1217486-61-7]

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Size	Unit Price	Stock
10 mg	$99.00	In Stock
50 mg	$297.00	In Stock

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Alpelisib - NVP-BYL719 | BYL-719

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Parent CAS No.

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Alpelisib - NVP-BYL719 | BYL-719

Description

Chemical name

Parent CAS No.

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