99% purity available from supplier Axon Medchem, prime source of life science reagents for your research" />

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LEE 011 - Ribociclib

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2273

CAS [1211441-98-3]

MF C23H30N8O
MW 434.54

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

LEE 011

Description

Orally bioavailable and highly selective small-molecule inhibitor of CDK4/6 (mean IC50 value 307 nM in sensitive neuroblastoma-derived cell lines). LEE011 caused cell-cycle arrest and cellular senescence that was attributed to dose-dependent decreases in phosphorylated RB and FOXM1, respectively. LEE 011 treatment of BE2C and IMR5 neuroblastoma cell lines with demonstrated sensitivity to CDK4/6 inhibition resulted in a dose-dependent accumulation of cells in the G0/G1 phase of the cell cycle.

KEYWORDS: LEE 011 | supplier | CDK4/6 inhibitor | Ribociclib | LEE011 | LEE-011 | CAS [1211441-98-3] | Cyclin Dependent | CDK4 | CDK6 | orally bioavailable | cell-cycle arrest | senescence | FOXM1

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Size Unit Price Stock
5 mg $77.00 In Stock
25 mg $154.00 In Stock
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Size Unit Price Stock
2 x 5 mg $110.00 In Stock
2 x 25 mg $220.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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