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Axon 2978
CAS [1197953-54-0]
MF C29H39ClN7O2PMW 584.09
Brigatinib is a potent and selective inhibitor of ALK (IC50 value of 0.6 nM), capable of overcoming mechanisms of resistance associated with crizotinib (Axon 1660). Besides inhibition of ALK, FLT3 and ROS1 were also potently inhibited. Brigatinib was highly active against both sensitive and resistant H3122 cells, decreasing cell growth, suppressing ALK phosphorylation, and inducing apoptosis.
KEYWORDS: Brigatinib | supplier | ALK inhibitor | AP 26113 | Alunbrig | AP26113 | AP-26113 | CAS [1197953-54-0] | Non Selective | ALK | ROS | FLT3 | Inhibitor | Receptors | EML4-ALK | Anaplastic Lymphoma Kinase
5-Chloro-N4-(2-(dimethylphosphoryl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
[1197953-54-0]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
Download the Axon Ligands™ catalogue 2021 Spring Edition
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