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XL 413 hydrochloride - BMS 863233 hydrochloride

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2268

CAS [2062200-97-7]

MF C14H12ClN3O2.HCl
MW 326.18

  • Purity: 99%
  • Soluble in water and DMSO

XL 413 hydrochloride

Description

Potent, selective and orally bioavailable CDC7 inhibitor (IC50 value of 3.4 nM) that shows >60-fold selectivity against CK2, >10-fold selectivity against PIM1, and >300-fold selectivity against a panel of over 100 protein kinases. XL 413 induces tumor cell apoptosis and inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells.Further development of XL 413 was terminated due to an unfavorable pharmacological profile observed in phase 1 clinical evaluation.
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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