CCT 137690

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1836

CAS [1095382-05-0]

MF C26H31BrN8O
MW 551.48

Purity: 98%
Moderately soluble in DMSO

CCT 137690

Description

Potent and orally bioavailable Aurora kinase inhibitor, with IC50 values to be 15, 25 and 19 nM for Aurora A, B and C kinases respectively

V Bavetsias et al. Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J. Med. Chem. 2010, 53(14), 5213-5228.

A Faisal et al. The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol. Cancer Ther. 2011, 10(11), 2115-2123.

Cell Cycle Regulation Cell Signaling & Oncology Epigenetics EC 2.7.11.1 Aurora

Aurora inhibitor (non-specific)

Chemical name

3-((4-(6-bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

Parent CAS No.

[1095382-05-0]

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10 mg	$126.50	In Stock
50 mg	$478.50	In Stock

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2 x 10 mg	$176.00	In Stock
2 x 50 mg	$660.00	In Stock

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CCT 137690

Description

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CCT 137690

Description

Chemical name

Parent CAS No.

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