GSK 2126458 - Omipalisib

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1596

CAS [1086062-66-9]

MF C25H17F2N5O3S
MW 505.50

Purity: 99%
Soluble in DMSO

GSK 2126458

Description

Highly potent and orally bioavailable inhibitor of PI3K and mTOR in vitro and in vivo; Ki values to be 0.019, 0.13, 0.024 and 0.06 nM for p110 α, β, δ and γ isoforms and 0.18 and 0.3 nM for mTORC1 and mTORC2 respectively.

SD Knight et al. Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin. ACS Med. Chem. Lett. 2010, 1(1), 39–43.

E Leung et al. Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells. Cancer Biol. Ther. 2011, 11(11), 938-946.

Cell Signaling & Oncology PI3K mTOR PI3K-Akt-mTOR EC 2.7.11.1

Dual PI3K and mTOR inhibitor

Chemical name

2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

Parent CAS No.

[1086062-66-9]

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Size	Unit Price	Stock
2 mg	$55.00	In Stock
5 mg	$88.00	In Stock
25 mg	$264.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	$132.00	In Stock
2 x 25 mg	$418.00	In Stock

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