Momelotinib - CYT387

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1681

CAS [1056634-68-4]

MF C23H22N6O2
MW 414.46

Purity: 99%
Soluble in DMSO

Momelotinib

Description

Selective and ATP-competitive Janus Kinase JAK1/JAK2 inhibitor, with IC50 to be 11 and 18 nM for JAK1 and JAK2 respectively and far less activity against other kinases, including JAK3 (IC50=155 nM). The hydrochloride salt form, Momelotenib hydrochloride (Axon 4124) is also available.

Keywords: Momelotinib | Supplier | JAK1/2 inhibitor | CYT387 | CYT-387 | CYT 387 | CAS [1056634-68-4] | JAK-STAT Pathway | JAK | Inhibitor | Enzymes

A Pardanan et al. CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia 2009, 23, 1441–1445.

JW Tyner et al. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood 2010, 115(25), 5232-5240.

S Verstovsek. Therapeutic potential of JAK2 inhibitors. Hematology Am Soc Hematol Educ Program. 2009, 636-642.

Cell Signaling & Oncology Epigenetics JAK-STAT EC 2.7.10.2 JAK

JAK1 and JAK2 inhibitor

Chemical name

N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide

Parent CAS No.

[1056634-68-4]

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Size	Unit Price	Stock
5 mg	$88.00	In Stock
25 mg	$264.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	$132.00	In Stock
2 x 25 mg	$396.00	In Stock

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Momelotinib - CYT387

Description

Chemical name

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