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- Pyrazinamide
Pyrazinamide
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 123.11 |
| Cas No. | 98-96-4 |
| Formula | C5H5N3O |
| Solubility | ≥2.94 mg/mL in EtOH with gentle warming and ultrasonic; ≥5.35 mg/mL in DMSO; ≥7.45 mg/mL in H2O with ultrasonic |
| Chemical Name | pyrazine-2-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | C1=CN=C(C=N1)C(=O)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
M. tuberculosis H37Rv |
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Preparation method |
The solubility of this compound in DMSO is ≥5.35mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
12 mg/ml |
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Applications |
Analysis of fatty acid synthesis in crude mycobacterial cell extracts demonstrated that pyrazinoic acid failed to directly modulate the fatty acid synthase activity catalyzed by fatty acid synthase I (FAS-I). However, fatty acid synthesis was irreversibly inhibited by 5-chloro-pyrazinamide in a time-dependent fashion. Moreover, we demonstrate that pyrazinoic acid does not inhibit purified mycobacterial FAS-I, suggesting that this enzyme is not the immediate target of pyrazinamide. |
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References: [1]. Boshoff HI, Mizrahi V, Barry CE 3rd. Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I. J Bacteriol. 2002 Apr;184(8):2167-72. PubMed PMID: 11914348; PubMed Central PMCID: PMC134955. |
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Quality Control & MSDS
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Chemical structure
