Lamotrigine
Catalog No.
B2249
5-HT inhibitor， sodium channel blocker
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Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
- 1. Juan Antonio Contreras Vite, Carlos Vega Valle, et al. "Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current INaby Lamotrigine; A Potential for Acquired Arrythmias." Pharmaceuticals (Basel). 2022 Sep 29;15(10):1208. PMID: 36297320
- 2. Sarah D. Burnett, Alexander D. Blanchette, et al. "Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors." Chem Res Toxicol. 2021 Sep 20;34(9):2110-2124. PMID: 34448577
- 3. Blanchette AD, Grimm FA, et al. "Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships." Clin Pharmacol Ther. 2018 Oct 22. PMID: 30346629
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 256.09 |
| Cas No. | 84057-84-1 |
| Formula | C9H7Cl2N5 |
| Solubility | insoluble in H2O; ≥12.3 mg/mL in DMSO; ≥2.18 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
Related Biological Data
