Aztreonam
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 435.43 |
| Cas No. | 78110-38-0 |
| Formula | C13H17N5O8S2 |
| Solubility | insoluble in EtOH; ≥10.24 mg/mL in H2O with ultrasonic; ≥18.9 mg/mL in DMSO |
| Chemical Name | 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid |
| SDF | Download SDF |
| Canonical SMILES | CC1C(C(=O)N1S(=O)(=O)O)NC(=O)C(=NOC(C)(C)C(=O)O)C2=CSC(=N2)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Human bone marrow cells |
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Preparation method |
The solubility of this compound in DMSO is ≥18.9 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
230.0mg/l, 5.0mg/l |
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Applications |
Aztreonam significantly inhibited human colony forming unit unit-erythroid (cfu-e), forming unit-erythroid (bfu-e) and colony forming units-granulocyte macrophages (cfu-gm) at peak and trough serum concentrations. |
| Animal experiment [1]: | |
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Animal models |
Male cynomolgus monkeys |
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Dosage form |
40,150 and 300 mg/kg(i.v.), once daily for 4 weeks |
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Application |
Treatment of cynomolgus monkeys with aztreonam at a dose of 40 to 300 mg / kg for 4 weeks resulted in a significant reduction in liver microsomal P450 content. On the other hand, after treatment with aztreonam, no significant changes in liver cytochrome b5 content and NADPH-cytochrome c (P450) reductase activity were observed. After treatment of cynomolgus monkeys with aztreonam, the activity of testosterone 6β-hydroxylase in liver microsomes decreased, but the activity of 2β- and 16α-hydroxylase did not decrease. Aztreonam reduced P450 CMLc in liver microsomes of cynomolgus monkeys. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Charak BS, Louie R, Malloy B, Twomey P, Mazumder A. The effect of amphotericin B, aztreonam, imipenem and cephalosporins on the bone marrow progenitor cell activity. J Antimicrob Chemother. 1991 Jan;27(1):95-104. PubMed PMID: 2050599. [2]. Ohmori S, Horie T, Hayashi S, Kitada M. Aztreonam decreases hepatic microsomal cytochrome P450 in cynomolgus monkeys. Pharmacology. 1994 Mar;48(3):137-42. PubMed PMID: 8153141. |
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Quality Control & MSDS
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Chemical structure
