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Sodium molybdate

Catalog No.
B7843
An acid phosphatase inhibitor
Grouped product items
SizePriceStock Qty
5g
$50.00
In stock
10g
$80.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Sodium molybdate is an acid phosphatase inhibitor. The osteoclastic acid phosphatase isoenzyme, secreted by osteoclasts, is a member of a widely-distributed class of iron-containing proteins with acid phosphatase activity. Elevated plasma isoenzyme levels are associated with increased bone turnover in metabolic disease. By inhibiting this class of acid phosphatases, sodium molybdate is capable of abolishing bone resorption. In addition, sodium molybdate has been shown to stabilize the nonactivated glucocorticoid-receptor complex.?

References:

1.?Zaidi M, Moonga B, Moss DW, et al. Inhibition of osteoclastic acid phosphatase abolishes bone resorption. Biochemical and Biophysical Research Communications, 1989, 159(1): 68-71.

2.?Denis M, Wikstr?m AC, Gustafsson JA. The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein. Journal of Biological Chemistry, 1987, 262(24): 11803-11806.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt205.94
Cas No.7631-95-0
FormulaMoNa2O4
Solubilityinsoluble in EtOH; insoluble in DMSO; ≥20.6 mg/mL in H2O
Chemical Namesodium molybdate
SDFDownload SDF
Canonical SMILES[O-][Mo](=O)([O-])=O.[Na+].[Na+]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]

Cell lines

Rat osteoclasts

Reaction Conditions

1 ~ 100 μM sodium molybdate

Applications

Addition of the phosphatase inhibitor sodium molybdate to the bone-osteoclast cultures at a concentration of 100 μM abolished bone resorption and reduced tartrate-resistant acid phosphatase activity by about 40%.

Note

The technical data provided above is for reference only.

References:

1. Zaidi M, Moonga B, Moss DW, et al. Inhibition of osteoclastic acid phosphatase abolishes bone resorption. Biochemical and Biophysical Research Communications, 1989, 159(1): 68-71.

2. Denis M, Wikstr?m AC, Gustafsson JA. The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein. Journal of Biological Chemistry, 1987, 262(24): 11803-11806.

Quality Control

Quality Control & MSDS

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Chemical structure

Sodium molybdate