Ketanserin

Catalog No.

B2248

specific 5-HT2A serotonin receptor antagonist

Grouped product items
Size	Price	Stock
50mg	$55.00	In stock
100mg	$88.00	In stock
500mg	$198.00	In stock

For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Background

Selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	395.43
Cas No.	74050-98-9
Formula	C₂₂H₂₂FN₃O₃
Solubility	≥39.5 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
Chemical Name	3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione
SDF	Download SDF
Canonical SMILES	C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Cell experiment:[1]
Cell lines	Isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins
Reaction Conditions	30 min incubation
Applications	Ketanserin dose-dependently inhibited contractile responses to 5-hydroxytryptamine (5-HT) in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic (threshold 10^-10 ~ 10^-9 M) and saphenous veins (threshold 10^-8 M).
Animal experiment:[2]
Animal models	Spontaneously hypertensive rats, 180 ~ 240 g
Dosage form	10 mg/kg/d Administered orally for 5 months
Applications	Ketanserin significantly decreased blood pressure and blood pressure variability, ameliorated impaired arterial baroreflex function, and significantly prevented the target organs of spontaneously hypertensive rats from being damaged.
Note	The technical data provided above is for reference only.
	References: 1. Van Nueten JM, Janssen PA, Van Beek J, et al. Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors. Journal of Pharmacology and Experimental Therapeutics, 1981, 218(1): 217-230. 2. Du WM, Miao CY, Liu JG, et al. Effects of long-term treatment with ketanserin on blood pressure variability and end-organ damage in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 2003, 41(2): 233-239.

Purity = 99.70%