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Hypoxanthine

Catalog No.
B3674
A naturally occurring purine derivative
Grouped product items
SizePriceStock Qty
50mg
$55.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Hypoxanthine is a natural purine derivative, with potential to be used as a free radical generator. Hypoxanthine seems to play a role in posthypoxic reoxygenation cell injury via oxygen radical production, and is thus involved in the pathogenesis of many diseases. Hypoxanthine also modulates a variety of other processes because it can react with benzodiazepine receptors and inhibit phosphodiesterase in the brain. Hypoxanthine has been reported to be used as an indicator of hypoxia.?

References:

1.?Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatric Research, 1988, 23(2): 143-150.

2.?Skolnick P, Marangos PJ, Goodwin FK, et al. Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous system. Life Sciences, 1978, 23(14): 1473-1480.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt136.11
Cas No.68-94-0
FormulaC5H4N4O
Solubilityinsoluble in EtOH; insoluble in H2O; ≥1.36 mg/mL in DMSO with ultrasonic; ≥5.89 mg/mL in EtOH with ultrasonic
SDFDownload SDF
Canonical SMILESO=C1N=CNC2=C1NC=N2
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[2]

Cell lines

Rat cerebral cortex synaptosomes

Reaction Conditions

400 μM

Applications

Hypoxanthine alone inhibited [3H] diazepam binding by 11.7%. When hypoxanthine was combined with inosine, the inhibition on [3H] diazepam binding could reach 34.3%. Thus, hypoxanthine could play a neuromodulatory role as well as affect benzodiazepine action.

Note

The technical data provided above is for reference only.

References:

1. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatric Research, 1988, 23(2): 143-150.

2. Skolnick P, Marangos PJ, Goodwin FK, et al. Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous system. Life Sciences, 1978, 23(14): 1473-1480.

Quality Control

Quality Control & MSDS

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Chemical structure

Hypoxanthine