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Avermectin B1b

Catalog No.
A3204
mixture of avermectins
Grouped product items
SizePriceStock Qty
500ug
$526.00
Ship with 5-10 days
2.5mg
$2,101.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Avermectin B1 is a mixture of avermectins containing >80% avermectin B1a and <20% avermectin B1b. B1a and B1b have very similar biological and toxicological properties.

In vitro: The avermectins are insecticidal and antihelmintic compounds derived from various laboratory broths fermented by the soil bacterium. Avermectin B1 is a natural fermentation product of this bacterium.

In vivo: Avermectin B1 therapy resulted in significant decreases in mean strongyle egg after treatment. All horses given ivermectin or avermectin B1 had zero strongyle egg counts 14 and 28 d after treatment. The oral administration of avermectin B1 appeared to be highly efficacious against intestinal strongyles and Onchocera microfilaria [1].

Clinical trial: Currently no clinical data are available

Reference:
[1] Mogg TD, Pollitt CC, Willmore JP, Thompson H.  Efficacy of avermectin B1 given orally against equine intestinal strongyles and Onchocera microfilaria. Aust Vet J. 1990;67(11):399-401.

Chemical Properties

Physical AppearanceA white solid
StorageStore at -20°C
M.Wt859.05
Cas No.65195-56-4
FormulaC47H70O14
SolubilitySoluble in DMSO
SDFDownload SDF
Canonical SMILESCC([C@](O1)([H])[C@@](C=C[C@@]21C[C@](O3)([H])C[C@@](O2)([H])C/C([H])=C([C@](O[C@@]4([H])C[C@@](OC)([H])[C@](O[C@@]5([H])C[C@@](OC)([H])[C@](O)([H])[C@](O5)([H])C)([H])[C@](O4)([H])C)([H])[C@@](/C([H])=C([H])/C([H])=C([C@@]67O)\CO[C@]7([H])[C@@](O)([H])C(
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment [1]：

Animal models

Horses and ponies

Dosage form

0.2 mg/kg (p.o.)

Application

Avermectin B1 treatment resulted in a significant decrease in the average number of strongyle egg counts the 14, 28 and 42 days. Oral administration of this avermectin B1 formulation appeared to be very effective against the intestinal strongyles and Onchocera microfilaria. However, the duration of anti- strongyle activity was much shorter than that of ivermectin paste.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Mogg TD, Pollitt CC, Willmore JP, Thompson H. Efficacy of avermectin B1 given orally against equine intestinal strongyles and Onchocera microfilaria. Aust Vet J. 1990 Nov;67(11):399-401. doi: 10.1111/j.1751-0813.1990.tb03026.x. PMID: 2085293.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Avermectin B1b