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Acetylcysteine
- 1. Minxin Wang, Jinyu Xu, et al. "Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition." Ecotoxicol Environ Saf. 2023 May:256:114876. PMID: 37027944
- 2. Shuyuan Yu, Huimin Zhao, et al. "Giardia duodenalis-induced G0/G1 intestinal epithelial cell cycle arrest and apoptosis involve activation of endoplasmic reticulum stress in vitro." Front Immunol. 2023 Mar 15:14:1127552. PMID: 37006313
- 3. Tong Wang, Qi Sun, et al. "A1 Reactive Astrocytes Activated by 2-chloroethanol Modulate M1 Microglia Polarization through Upregulating IL-1β and TNF-α." Research Square. April 13th, 2021
- 4. Tong Wang, Qi Sun, et al. "A1 astrocytes activated by 2-Chloroethanol via the ROS-induced p38 MAPK/NF-κB and AP-1 pathways modulate microglia polarization." Research Square. April 12th, 2021.
- 5. PIUS REYDERG AGYEMANG. "Profifiling of FDA-Approved and Clinical Trial Drugs Revealed Shared Cytotoxicity And Collateral Sensitivity In Resistant (H69ar) And Non-Resistant (H69) Small Cell Lung Cancer Cells. (Drug Repurposing in Cancer Chemotherapy)." South Dakota State University 2021.
- 6. Jing Wu, Yan-Qiu You, et al. "DDX5-targeting fully human monoclonal autoantibody inhibits proliferation and promotes differentiation of acute promyelocytic leukemia cells by increasing ROS production." Cell Death & Disease volume 11, Article number: 552 (2020);20 July 2020. PMID: 32690860
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| Storage | Store at -20°C |
| M.Wt | 163.19 |
| Cas No. | 616-91-1 |
| Formula | C5H9NO3S |
| Synonyms | N-acetylcysteine; N-acetyl-L-cysteine; NAC; Acetadote |
| Solubility | ≥44.6 mg/mL in H2O; ≥53.3 mg/mL in EtOH; ≥8.16 mg/mL in DMSO |
| Chemical Name | (2R)-2-acetamido-3-sulfanylpropanoic acid |
| SDF | Download SDF |
| Canonical SMILES | CC(=O)NC(CS)C(=O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
PC12 cells |
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Preparation method |
The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
1–1000 μM; 3h |
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Applications |
In PC12 cells, Acetylcysteine (NAC) produced concentration-dependent decreases in DOPAL levels. Co-incubation of NAC (1-10 μM) with selegiline (1 μM) attenuated or prevented the Cys-DA response to selegiline, without interfering with the selegiline-induced decrease in DOPAL production or inhibiting tyrosine hydroxylation. |
| Animal experiment [2]: | |
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Animal models |
the R6/1 transgenic mouse model of Huntington’s disease (HD) |
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Dosage form |
500 mg/kg i.p., 4 weeks |
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Application |
In the R6/1 transgenic mouse model of Huntington’s disease (HD), Acetylcysteine (NAC)-HD mice showed forced-swim test (FST) immobility times intermediate to saline-HD and saline-WT mice. NAC exhibited antidepressant-like effect. HD mice co-administered with CPG (inhibitor of GLT-1) and NAC showed higher immobility times than NAC-HD mice, suggesting that the antidepressant-like effect of NAC is dependent on glutamate transport. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Goldstein DS1, Jinsmaa Y2, Sullivan P2, et al. N-Acetylcysteine Prevents the Increase in Spontaneous Oxidation of Dopamine During Monoamine Oxidase Inhibition in PC12 Cells. Neurochem Res. 2017 Aug 24. [2] Wright DJ1,2, Gray LJ3,2, Finkelstein DI1, et al. N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease. Hum Mol Genet. 2016 Jul 15;25(14):2923-2933. |
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Quality Control & MSDS
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Chemical structure
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