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Olsalazine Sodium

Catalog No.
A8490
Anti-inflammatory prodrug
Grouped product items
SizePriceStock Qty
10mM (in 1mL H2O)
$77.00
In stock
5g
$69.00
In stock
10g
$116.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Olsalazine Sodium is a mesalamine dimer.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt346.2
Cas No.6054-98-4
FormulaC14H8N2O6·2Na
Solubilityinsoluble in DMSO; insoluble in EtOH; ≥17.2 mg/mL in H2O
Chemical Namedisodium;5-[2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-oxidobenzoate
SDFDownload SDF
Canonical SMILESC1=CC(=C(C=C1NN=C2C=CC(=O)C(=C2)C(=O)O)C(=O)[O-])[O-].[Na+].[Na+]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment [1]:

Cell lines

Macrophages

Preparation method

The solubility of this compound in H2O is ≥17.2mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

0-26nM

Applications

Olsalazine was a potent inhibitor of chemotaxis of LTB4 by macrophages with IC50 value of 0.39nM.
Animal experiment [1]:

Animal models

Colorectal cancer tumor model in male rats

Dosage form

25 mg/kg/day(p.o.)

Application

In a rodent model with colon cancer, olsalazine effectively reduced the number and load of tumors, increased the rate of tumor apoptosis, and reduced the rate of tumor cell proliferation and inhibited tumor growth.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Kong D, Yun H, Cui D, Qi M, Shao C, Cui D, Ren N, Liang B, Wang A. Response of antimicrobial nitrofurazone-degrading biocathode communities to different cathode potentials. Bioresour Technol. 2017 Oct; 241:951-958. doi:10.1016/j.biortech.2017.06.056. Epub 2017 Jun 13. PubMed PMID: 28637162.

[2]. Brown WA, Farmer KC, Skinner SA, Malcontenti-Wilson C, Misajon A, O'Brien PE. 5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer. Dig Dis Sci. 2000 Aug;45(8):1578-84. PubMed PMID: 11007109.

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