Megestrol Acetate
Megestrol Acetate is a synthetic progesteronal and potent anti-estrogen agent with multiple drug actions [1].
Megestrol Acetate has been reported to cause minor reduction of tumor size and prolonged survival time in Hepatocellular carcinoma (HCC). In addition, Megestrol Acetate has shown the dose-dependent inhibition on growth of the human liver tumor cells in the HepG2 cell lines with the IC50 value of 260μM in vitro. Furthermore, Megestrol Acetate has also shown a significant suppression of tumor growth. The tumor volumes of the addition of Megestrol Acetate group regressed to 59% of controls at 6th week. Apart from these, Megestrol Acetate has been revealed to increase the cell numbers of sub-G1 and inhibit the cell cycle progression in both dose- and time–dependent fashion. Besides, Megestrol Acetate has been demonstrated to induce apoptosis of HepG2 cells [1].
References:
[1] Zhang K1, Chow PK. The effect of megestrol acetate on growth of HepG2 cells in vitro and in vivo. Clin Cancer Res. 2004 Aug 1; 10(15):5226-32.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 384.51 |
| Cas No. | 595-33-5 |
| Formula | C24H32O4 |
| Solubility | insoluble in H2O; ≥2.54 mg/mL in EtOH with gentle warming; ≥3.84 mg/mL in DMSO with gentle warming |
| Chemical Name | [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
