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- S-(2-aminoethyl) Isothiourea (dihydrobromide)
S-(2-aminoethyl) Isothiourea (dihydrobromide)
S-(2-aminoethyl) Isothiourea (dihydrobromide) is a potent and non-selective inhibitor of NOS with Ki values of 1.8, 2.1, and 0.59 μM for human nNOS, eNOS, and iNOS, respectively [1].
In the brain, nitric oxide (NO), which is synthesized from L-arginine (Arg) by NO synthase (NOS), acts as both an intra- and an intercellular second messenger. Nitric oxide synthase (iNOS, eNOS, and nNOS) catalyzed the production of NO in the two-step oxidation of L-arginine. The three isozymes produce NO in separate tissues for different purposes in both normal and diseased states [1].
S-(2-aminoethyl) Isothiourea is a potent and non-selective NOS inhibitor with Ki values of 1.8, 2.1, and 0.59 μM for human nNOS, eNOS, and iNOS, respectively [1].
Reference:
[1]. Garvey EP, Oplinger JA, Tanoury GJ, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem. 1994 Oct 28;269(43):26669-76.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 281.0 |
Cas No. | 56-10-0 |
Formula | C3H9N3S · 2HBr |
Synonyms | Antiradon,NSC 22877 |
Solubility | ≤10mg/ml in H2O |
Chemical Name | 2-aminoethyl carbamimidothioate, dihydrobromide |
SDF | Download SDF |
Canonical SMILES | N/C(SCCN)=N/[H].Br.Br |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
