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S-(2-aminoethyl) Isothiourea (dihydrobromide)

Catalog No.
C5723
non-selective inhibitor of all NOS isoforms
Grouped product items
SizePriceStock Qty
25g
$80.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

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Email: [email protected]

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Background

S-(2-aminoethyl) Isothiourea (dihydrobromide) is a potent and non-selective inhibitor of NOS with Ki values of 1.8, 2.1, and 0.59 μM for human nNOS, eNOS, and iNOS, respectively [1].

In the brain, nitric oxide (NO), which is synthesized from L-arginine (Arg) by NO synthase (NOS), acts as both an intra- and an intercellular second messenger. Nitric oxide synthase (iNOS, eNOS, and nNOS) catalyzed the production of NO in the two-step oxidation of L-arginine. The three isozymes produce NO in separate tissues for different purposes in both normal and diseased states [1].

S-(2-aminoethyl) Isothiourea is a potent and non-selective NOS inhibitor with Ki values of 1.8, 2.1, and 0.59 μM for human nNOS, eNOS, and iNOS, respectively [1].

Reference:
[1].  Garvey EP, Oplinger JA, Tanoury GJ, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem. 1994 Oct 28;269(43):26669-76.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt281.0
Cas No.56-10-0
FormulaC3H9N3S · 2HBr
SynonymsAntiradon,NSC 22877
Solubility≤10mg/ml in H2O
Chemical Name2-aminoethyl carbamimidothioate, dihydrobromide
SDFDownload SDF
Canonical SMILESN/C(SCCN)=N/[H].Br.Br
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

S-(2-aminoethyl) Isothiourea (dihydrobromide)