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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Tamoxifen Citrate is an antiestrogen drug [1].
Tamoxifen Citrate has been reported to act as an anti-estrogen and inhibit the binding of estrogen to estrogen receptors. Tamoxifen has shown the activity to inhibit tumor growth because of the function of estrogen-antagonist activity in breast tissue. In addition, Tamoxifen has been revealed to inhibit the expression of estrogen-regulated genes, including growth factors and angiogenic factors secreted by the tumor. Tamoxifen has also shown the block in the G1 phase of cell cycle and a slowing cell proliferation. Furthermore, Tamoxifen has been noted to directly induce programmed cell death [1].
References:[1] Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18.
