成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Toggle Nav
Close
  • Menu
  • Setting

Kaempferol

Catalog No.
N1719
Apoptosis inducer;antioxidant;flavonoid
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$61.00
In stock
50mg
$55.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt286.24
Cas No.520-18-3
FormulaC15H10O6
SynonymsKempferol
Solubilityinsoluble in H2O; insoluble in EtOH; ≥12.25 mg/mL in DMSO
Chemical Name3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
SDFDownload SDF
Canonical SMILESC1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment [1]:

Cell lines

The human cholangiocarcinoma (CCA) cell lines HCCC9810 and QBC939

Preparation method

The solubility of this compound in DMSO is >12.3mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

0, 30, 60, 90, 120, or 150 μM; 24, 48, or 72 h; 37°C

Applications

In CCA cells, kaempferol significantly inhibited the viability and proliferation of CCA cells in a time- and dose-dependent way. Kaempferol reduced the number of colonies and induced apoptosis in a dose-dependent way. Kaempferol also reduced the migration and invasion ability of CCA cells in a dose-dependent manner.
Animal experiment [1]:

Animal models

subcutaneous xenograft nude mice model

Dosage form

20 mg/kg/day; daily for 3 weeks; i.p.

Application

In subcutaneous xenograft nude mice model, kaempferol significantly inhibited the growth of the tumor. The number of Ki-67-positive tumor cells was lower in kaempferol-treated group than that in the control group. Kaempferol reduced the average volume and number of foci per mouse.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Qin Y1, Cui W2, Yang X2, et al. Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2016 Mar;48(3):238-45.

Quality Control