Spironolactone
Catalog No.
B1378
Competitive mineralocorticoid (aldosterone) receptor antagonist
Featured Products
Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.
- 1. Shaj K, Hutcherson RJ, et al. "ATR Kinase Activity Limits Mutagenesis and Promotes the Clonogenic Survival of Quiescent Human Keratinocytes Exposed to UVB Radiation." Photochem Photobiol. 2019 Sep 25. PMID:31554014
- 2. KAVYA SHAJ. "DIFFERING FUNCTIONS OF ATR KINASE IN HUMAN EPIDERMAL KERATINOCYTES EXPOSED TO ULTRAVIOLET B RADIATION." Wright State University. 2019.
- 3.Kemp MG. "DNA damage-induced ATR kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor II-H (TFIIH)." J Biol Chem. 2017 Jun 7. pii: jbc.M117.788406. PMID:28592488
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 416.57 |
| Cas No. | 52-01-7 |
| Formula | C24H32O4S |
| Solubility | insoluble in H2O; ≥16.23 mg/mL in EtOH; ≥18 mg/mL in DMSO |
| Chemical Name | S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate |
| SDF | Download SDF |
| Canonical SMILES | CC(=O)SC1CC2=CC(=O)CCC2(C3C1C4CCC5(C4(CC3)C)CCC(=O)O5)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
