Resveratrol
Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
- 1. Xin Chou, Xiaohu Li, et al. "Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation." Ecotoxicol Environ Saf. 2022 Oct 15;245:114098. PMID: 36137422
- 2. Li Y, Xi Y, et al. "Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-κB signaling pathway."?Int Immunopharmacol. 2020;83:106386. PMID: 32193100
- 3. Song Y, Chen Y, et al. "Resveratrol Suppresses Epithelial-Mesenchymal Transition in GBM by Regulating Smad-Dependent Signaling." Biomed Res Int. 2019 Apr 7;2019:1321973. PMID: 31119150
- 4. Chou X, Ding F, et al. "Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells." Arch Toxicol. 2019 Feb 22. PMID: 30796460
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 228.24 |
| Cas No. | 501-36-0 |
| Formula | C14H12O3 |
| Solubility | insoluble in H2O; ≥48.2 mg/mL in EtOH with ultrasonic; ≥9.65 mg/mL in DMSO |
| Chemical Name | 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
|
Cell lines |
primary neuronal cultures; the neuroblastoma SH-SY5Y cell line |
|
Preparation method |
The solubility of this compound in DMSO is >9.7 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37°C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
|
Reacting condition |
0.1, 1, and 10 μM; 50 μM |
|
Applications |
In primary neuronal cultures, resveratrol (0.1, 1, and 10 μM) inhibited OGD/reperfusion-induced apoptosis and inhibited the overexpression of caspase-3 and caspase-12 mRNA in a concentration-dependent way. In the neuroblastoma SH-SY5Y cell line, resveratrol (50 μM) inhibited excess dopamine-induced cell death by ameliorating intracellular oxidative stress and increasing the activity of prosurvival gene Bcl-2. |
| Animal experiment [2]: | |
|
Animal models |
rats subjected to myocardial ischemia |
|
Dosage form |
2.5, 5.0, 25 or 50 mg/kg; fed for 14 days by gavaging |
|
Application |
In rats subjected to myocardial ischemia, resveratrol (2.5, 5.0 mg/kg) exhibited cardioprotection by improved post-ischemic ventricular recovery and reduction of myocardial infarct size and cardiomyocyte apoptosis. However, 25 or 50 mg/kg dose of resveratrol inhibited cardiac function and increased myocardial infarct size and number of apoptotic cells. |
|
Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
|
References: [1] Nilendra Singh, Megha Agrawal, and Sylvain Doré. Neuroprotective Properties and Mechanisms of Resveratrol in in Vitro and in Vivo Experimental Cerebral Stroke Models. ACS Chem Neurosci. 2013 Aug 21; 4 (8): 1151–1162. [2] Dudley J1, Das S, Mukherjee S, et al. Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose. J Nutr Biochem. 2009 Jun; 20 (6): 443-52. |
|
Quality Control & MSDS
- View current batch:
Chemical structure
Related Biological Data
Related Biological Data
Related Biological Data
Related Biological Data
