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Aspirin (Acetylsalicylic acid)

Catalog No.
A4013
Cyclooxygenase (COX) inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$61.00
In stock
1g
$55.00
In stock
5g
$88.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Aspirin (Acetylsalicylic acid) is a potent and selective inhibitor of cyclooxygenase (COX) with a broad range of pharmacological activities including anti-inflammation and pain relief. Multiple studies have accumulated sufficient evidence to establish the association between the use of aspirin and a reduced risk of cancers including prostate cancer, breast cancer, colorectal cancer, endometrial cancer, and ovarian cancer. Aspirin suppresses ovarian cancer cells harboring COX-1 by acting as histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21. Aspirin also inhibits the expression of COX-2 in human umbilical vein endothelial cells and neonatal rat ventricular cardiomyocytes resulting in reduced PG production and the down-regulation of ERK and NF-KB respectively.

Reference

Cho M, Kabir SM, Dong Y, Lee E, Rice VM, Khabele D, Son DS. Aspirin Blocks EGF-stimulated Cell Viability in a COX-1 Dependent Manner in Ovarian Cancer Cells. J Cancer. 2013;4(8):671-678.

Duan Y, Chen F, Zhang A, Zhu B, Sun J, Xie Q, Chen Z. Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity. BMB Rep. 2013. pii: 2320. [Epub ahead of print]

Chemical Properties

StorageStore at -20°C
M.Wt180.16
Cas No.50-78-2
FormulaC9H8O4
Synonyms2-Acetoxybenzoic acid, Acylpyrin, Ecotrin, Acenterine, Polopiryna, Acetosal
Solubilityinsoluble in H2O; ≥104.2 mg/mL in EtOH with ultrasonic; ≥8.55 mg/mL in DMSO
Chemical Name2-acetyloxybenzoic acid
SDFDownload SDF
Canonical SMILESCC(=O)OC1=CC=CC=C1C(=O)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]

Cell lines

Porcine alveolar macrophages

Reaction Conditions

3 mM aspirin for 30 min pretreatment

Applications

Aspirin inhibited lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity.
Animal experiment:[2]

Animal models

Male albino Charles River rats weighing between 200 and 250 g

Dosage form

5, 25, 50, 100 and 150 mg/kg

Administered orally

Applications

Aspirin, administered orally at 5, 25, 50 and 100 mg/kg, exhibited antipyretic activity at all doses. The ED50 values calculated from these data ranged from 10.3 to 21.1 mg/kg. In addition, statistically significant antipyresis was demonstrated 15 min after an oral dose of 150 mg/kg of aspirin, with the maximum effect occurred at 120 min.

Note

The technical data provided above is for reference only.

References:

1. Duan Y, Chen F, Zhang A, et al. Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity. BMB Reports, 2014, 47(1): 45-50.

2. Loux JJ, DePalma PD, Yankell SL. Antipyretic testing of aspirin in rats. Toxicology and Applied Pharmacology, 1972, 22(4): 672-675.

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